2.7.7.89: [glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
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Reaction
Synonyms
adenylyl(glutamine synthetase) hydrolase, adenylyl-[glutamine-synthetase] hydrolase, EC 3.1.4.15, GlnE, hydrolase adenylyl(glutamine synthetase), [glutamate-ammonia ligase]-adenylyl-L-tyrosine phosphorylase
ECTree
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Inhibitors
Inhibitors on EC 2.7.7.89 - [glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
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2-oxoglutarate
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controls the extent of activation or inhibition of the enzyme by PII or PII-UMP. 2-Oxoglutarate acts exclusively through its binding to PII and PII-UMP, and does not alter the binding of PII or PII-UMP to the enzyme
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the adenylyl-removing reaction is activated by PII-UMP and is inhibited by glutamine and by PII. PII, PII-UMP, and glutamine shift the enzyme among at least six different enzyme forms, two of which are inactive, one of which exhibits adenylyl-removing activity, and three of which exhibit adenylyltranferase activity. The PII, PII-UMP, and glutamine binding sites are in communication. Glutamine and PII-UMP compete for the enzyme
glutamine
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glutamine inhibition of the adenylyl-removing activity involves intramolecular signaling between the adenylyltransferase and adenylyl-removing domains
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the adenylyl-removing reaction is activated by PII-UMP and is inhibited by glutamine and by PII. The adenylyltransferase reaction is activated by glutamine and by the unmodified form of the PII signal transduction protein and is inhibited by the uridylylated form of PII, PII-UMP. PII, PII-UMP, and glutamine shift the enzyme among at least six different enzyme forms, two of which are inactive, one of which exhibits adenylyl-removing activity, and three of which exhibit adenylyltranferase activity. The enzyme appears to contain two distinct sites for PII and PII-UMP. The PII, PII-UMP, and glutamine sites are in communication. The binding of PII is favored by glutamine and its level reduced by PII-UMP, whereas glutamine and PII-UMP compete for the enzyme
signal transduction protein PII
the deadenylylation activity of AT-N is inhibited by PII
signal transduction protein PII
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a tetrameric PIID molecule interacts with only one enzyme molecule at a time