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2.6.1.44: alanine-glyoxylate transaminase

This is an abbreviated version!
For detailed information about alanine-glyoxylate transaminase, go to the full flat file.

Word Map on EC 2.6.1.44

Reaction

L-alanine
+
glyoxylate
=
pyruvate
 +
glycine

Synonyms

3-hydroxykynurenine transaminase, 3-hydroxykynurenine transaminase/alanine glyoxylate transaminase, AGT, AGT-Ma, AGT-Mi, AGT1, AGT2, AGX, AGXT, AGXT2, alanine aminotransferase, alanine glyoxalate transaminase 2, alanine glyoxylate aminotransferase, alanine-glyoxalate aminotransferase, alanine-glyoxalate transaminase 1, alanine-glyoxylate aminotransferase, alanine-glyoxylate aminotransferase 2, alanine-glyoxylate aminotransferase isoenzyme 2, alanine-glyoxylate aminotransferase-2, alanine-glyoxylic aminotransferase, alanine: glyoxylate aminotransferase, alanine:2-oxoglutarate aminotransferase, alanine:glyoxylate aminotransferase, alanine:glyoxylate aminotransferase 1, alanine:glyoxylate aminotransferase 2, alanine:glyoxylate aminotransferase type 1, alanine:glyoxylate aminotransferase/beta-alanine:pyruvate aminotransferase, aminotransferase 3, AT3, At3g08860, cytosolic alanine aminotransferase, D-AIB AT, EC 2.6.1.51, GGT, glyoxylate aminotransferase AGT1, L-alanine-glycine transaminase, L-alanine-glyoxylate aminotransferase, L-alanine:glyoxylate aminotransferase, More, serine pyruvate aminotransferase, serine:pyruvate/alanine:glyoxylate aminotransferase, SPT/AGT

ECTree

     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.44 alanine-glyoxylate transaminase

Inhibitors

Inhibitors on EC 2.6.1.44 - alanine-glyoxylate transaminase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
amino-oxyacetic acid
aminooxyacetic acid
-
D-alanine
competitive inhibitor with L-alanine as varied substrate and glyoxylate as fixed substrate. Uncompetitive inhibitor with glyoxylate as varied substrate and L-alanine as fixed substrate; competitive with L-alanine, uncompetitive with glyoxylate
D-cycloserine
DCS, commercialized as Seromycin, a reversible inhibitor of AGT. DCS displays a time-dependent binding mainly generating an oxime intermediate, inhibition mechanism, overview
glycine
-
linear competitive inhibitor
glyoxylate
-
above 5 mM
hydroxylamine
Isonicotinic acid hydrazide
L-Cycloserine
LCS, a reversible inhibitor of AGT. LCS undergoes half-transamination generating a ketimine intermediate and behaves as a classical competitive inhibitor, inhibition mechanism, overview
L-glutamate
L-Penicillamine
-
10 mM, 86% inhibition
pyruvate
mixed type inhibition with L-alanine, competitive with glyoxylate; mixed type inhibitor with L-alanine as varied substrate and glyoxylate as fixed substrate. Competitive inhibitor with glyoxylate as varied substrate and L-alanine as fixed substrate
Semicarbazide
additional information
-