Activating Compound | Comment | Organism | Structure |
---|---|---|---|
glucagon | induced by, isoenzyme 1 is increased in activity | Mus musculus | |
glucagon | induced by, isoenzyme 1 is increased in activity | Rattus norvegicus | |
glucagon | induced by, isoenzyme 1 is increased in activity | Canis lupus familiaris | |
glucagon | induced by, isoenzyme 1 is increased in activity | Felis catus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
hydroxylamine | isoenzyme 1 | Canis lupus familiaris | |
hydroxylamine | isoenzyme 1 | Felis catus | |
hydroxylamine | isoenzyme; isoenzyme 1 | Mus musculus | |
hydroxylamine | isoenzyme; isoenzyme 1 | Rattus norvegicus | |
Isonicotinic acid hydrazide | isoenzyme 1 and isoenzyme 2 | Mus musculus | |
Isonicotinic acid hydrazide | isoenzyme 1 and isoenzyme 2 | Rattus norvegicus | |
Semicarbazide | isoenzyme 1 | Canis lupus familiaris | |
Semicarbazide | isoenzyme 1 | Felis catus | |
Semicarbazide | isoenzyme; isoenzyme 1 | Mus musculus | |
Semicarbazide | isoenzyme; isoenzyme 1 | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.07 | - |
glyoxylate | pH 8.2, 37°C, isoenzyme 1, alanine as amino donor | Rattus norvegicus | |
0.1 | - |
glyoxylate | pH 8.2, 37°C, isoenzyme 1, alanine as amino donor | Felis catus | |
0.13 | - |
glyoxylate | pH 8.2, 37°C, isoenzyme 1, alanine as amino donor | Canis lupus familiaris | |
0.2 | - |
glyoxylate | pH 8.2, 37°C, isoenzyme 1, alanine as amino donor | Mus musculus | |
0.72 | - |
glyoxylate | pH 8.0, 37°C, alanine as amino donor | Mus musculus | |
1 | - |
glyoxylate | pH 8.2, 37°C, isoenzyme 2, alanine as amino donor | Rattus norvegicus | |
1.4 | - |
L-alanine | pH 8.2, 37°C, isoenzyme 1, glyoxylate as amino acceptor | Mus musculus | |
2.1 | - |
L-alanine | pH 8.2, 37°C, isoenzyme 1, glyoxylate as amino acceptor | Rattus norvegicus | |
3 | - |
L-alanine | pH 8.2, 37°C, isoenzyme 1, glyoxylate as amino acceptor | Canis lupus familiaris | |
3.9 | - |
L-alanine | pH 8.2, 37°C, isoenzyme 1, glyoxylate as amino acceptor | Canis lupus familiaris | |
25 | - |
L-alanine | pH 8.2, 37°C, isoenzyme 2, glyoxylate as amino acceptor | Mus musculus | |
30 | - |
L-alanine | pH 8.2, 37°C, isoenzyme 2, glyoxylate as amino acceptor | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
38000 | - |
2 * 38000, isoenzyme 1, SDS-PAGE | Mus musculus |
38000 | - |
2 * 38000, isoenzyme 1, SDS-PAGE | Rattus norvegicus |
38000 | - |
2 * 38000, isoenzyme 1, SDS-PAGE | Canis lupus familiaris |
38000 | - |
2 * 38000, isoenzyme 1, SDS-PAGE | Felis catus |
77000 | - |
- |
Mus musculus |
77000 | - |
- |
Canis lupus familiaris |
77000 | - |
- |
Felis catus |
77000 | - |
isoenzyme 1, gel filtration | Rattus norvegicus |
80000 | - |
sucrose-density-gradient centrifugation | Mus musculus |
80000 | - |
sucrose-density-gradient centrifugation | Rattus norvegicus |
80000 | - |
sucrose-density-gradient centrifugation | Canis lupus familiaris |
80000 | - |
sucrose-density-gradient centrifugation | Felis catus |
80000 | - |
peroxisomal and mitochondrial alanine-glyoxylate aminotransferase 1 | Rattus norvegicus |
170000 | - |
isoenzyme 2, gel filtration | Rattus norvegicus |
175000 | - |
- |
Canis lupus familiaris |
175000 | - |
liver isoenzyme 2, gel filtration | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-alanine + glyoxylate | Mus musculus | - |
pyruvate + glycine | - |
ir | |
L-alanine + glyoxylate | Rattus norvegicus | - |
pyruvate + glycine | - |
ir | |
L-alanine + glyoxylate | Canis lupus familiaris | - |
pyruvate + glycine | - |
ir | |
L-alanine + glyoxylate | Felis catus | - |
pyruvate + glycine | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
dog | - |
Felis catus | - |
cat | - |
Mus musculus | - |
mouse | - |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
isoenzyme 1 | Canis lupus familiaris |
isoenzyme 1 | Felis catus |
isoenzyme 1 and 2 | Mus musculus |
isoenzyme 1 and 2 | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Canis lupus familiaris | - |
liver | - |
Felis catus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
2.64 | - |
isoenzyme 2 | Canis lupus familiaris |
2.93 | - |
- |
Rattus norvegicus |
2.93 | - |
isoenzyme 2 | Canis lupus familiaris |
21.4 | - |
isoenzyme 1 | Rattus norvegicus |
23.2 | - |
isoenzyme 1 | Mus musculus |
86.3 | - |
isoenzyme 1 | Felis catus |
91 | - |
isoenzyme 1 | Canis lupus familiaris |
160 | - |
isoenzyme 1 | Rattus norvegicus |
Storage Stability | Organism |
---|---|
-20°C, 50 mM potassium phosphate buffer, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 4 weeks without loss of either activity | Rattus norvegicus |
-20°C, 50 mM potassium phosphate buffer, pH 7.5, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 4 weeks without loss of either activity | Mus musculus |
-20°C, 50 mM potassium phosphate buffer, pH 7.5, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 4 weeks without loss of either activity | Canis lupus familiaris |
-20°C, 50 mM potassium phosphate buffer, pH 7.5, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 4 weeks without loss of either activity | Felis catus |
0-6°C, 50 mM potassium phosphate buffer, pH 7.5, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 2 weeks with little loss of either activity | Mus musculus |
0-6°C, 50 mM potassium phosphate buffer, pH 7.5, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 2 weeks with little loss of either activity | Rattus norvegicus |
0-6°C, 50 mM potassium phosphate buffer, pH 7.5, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 2 weeks with little loss of either activity | Canis lupus familiaris |
0-6°C, 50 mM potassium phosphate buffer, pH 7.5, 0.1 mM pyridoxal 5'-phosphate, 1 mM 2-mercaptoethanol, may be stored for at least 2 weeks with little loss of either activity | Felis catus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-alanine + glyoxylate | - |
Mus musculus | pyruvate + glycine | - |
ir | |
L-alanine + glyoxylate | - |
Rattus norvegicus | pyruvate + glycine | - |
ir | |
L-alanine + glyoxylate | - |
Canis lupus familiaris | pyruvate + glycine | - |
ir | |
L-alanine + glyoxylate | - |
Felis catus | pyruvate + glycine | - |
ir | |
L-alanine + glyoxylate | isoenzyme 1 | Mus musculus | pyruvate + glycine | - |
ir | |
L-alanine + glyoxylate | isoenzyme 1 | Rattus norvegicus | pyruvate + glycine | - |
ir | |
L-alanine + glyoxylate | isoenzyme 2 highly specific, little or no activity with other amino donors/acceptors | Mus musculus | pyruvate + glycine | - |
ir | |
L-alanine + glyoxylate | isoenzyme 2 highly specific, little or no activity with other amino donors/acceptors | Rattus norvegicus | pyruvate + glycine | - |
ir | |
L-alanine + hydroxypyruvate | - |
Canis lupus familiaris | pyruvate + L-serine | - |
ir | |
L-alanine + hydroxypyruvate | - |
Felis catus | pyruvate + L-serine | - |
ir | |
L-alanine + hydroxypyruvate | isoenzyme 1 | Mus musculus | pyruvate + L-serine | - |
ir | |
L-alanine + hydroxypyruvate | isoenzyme 1 | Rattus norvegicus | pyruvate + L-serine | - |
ir | |
L-alanine + phenylpyruvate | isoenzyme 1 | Mus musculus | pyruvate + L-phenylalanine | - |
ir | |
L-alanine + phenylpyruvate | isoenzyme 1 | Rattus norvegicus | pyruvate + L-phenylalanine | - |
ir | |
L-alanine + phenylpyruvate | isoenzyme 1, less effectively acceptor | Canis lupus familiaris | pyruvate + L-phenylalanine | - |
ir | |
L-alanine + phenylpyruvate | isoenzyme 1, less effectively acceptor | Felis catus | pyruvate + L-phenylalanine | - |
ir | |
L-asparagine + glyoxylate | isoenzyme 1 | Mus musculus | 4-amino-2,4-dioxobutanoate + glycine | - |
ir | |
L-asparagine + glyoxylate | isoenzyme 1 | Rattus norvegicus | 4-amino-2,4-dioxobutanoate + glycine | - |
ir | |
L-glutamine + glyoxylate | isoenzyme 1 | Mus musculus | 2-oxoglutaramate + glycine | - |
ir | |
L-glutamine + glyoxylate | isoenzyme 1 | Rattus norvegicus | 2-oxoglutaramate + glycine | - |
ir | |
L-histidine + glyoxylate | isoenzyme 1 | Mus musculus | 3-(1H-imidazol-4-yl)-2-oxopropanoate + glycine | - |
ir | |
L-histidine + glyoxylate | isoenzyme 1 | Rattus norvegicus | 3-(1H-imidazol-4-yl)-2-oxopropanoate + glycine | - |
ir | |
L-isoleucine + glyoxylate | isoenzyme 1 | Mus musculus | 3-methyl-2-oxopropanoate + glycine | - |
ir | |
L-leucine + glyoxylate | isoenzyme 1 | Mus musculus | 4-methyl-2-oxopentanoate + glycine | - |
ir | |
L-leucine + glyoxylate | isoenzyme 1 | Rattus norvegicus | 4-methyl-2-oxopentanoate + glycine | - |
ir | |
L-methionine + glyoxylate | isoenzyme 1 | Mus musculus | 4-methylsulfanyl-2-oxobutanoate + glycine | - |
ir | |
L-methionine + glyoxylate | isoenzyme 1 | Rattus norvegicus | 4-methylsulfanyl-2-oxobutanoate + glycine | - |
ir | |
L-phenylalanine + glyoxylate | isoenzyme 1 | Mus musculus | phenylpyruvate + glycine | - |
ir | |
L-phenylalanine + glyoxylate | isoenzyme 1 | Rattus norvegicus | phenylpyruvate + glycine | - |
ir | |
L-serine + glyoxylate | - |
Canis lupus familiaris | 3-hydroxy-2-oxopropanoate + glycine | - |
ir | |
L-serine + glyoxylate | - |
Felis catus | 3-hydroxy-2-oxopropanoate + glycine | - |
ir | |
L-serine + glyoxylate | isoenzyme 1 | Mus musculus | 3-hydroxy-2-oxopropanoate + glycine | - |
ir | |
L-serine + glyoxylate | isoenzyme 1 | Rattus norvegicus | 3-hydroxy-2-oxopropanoate + glycine | - |
ir | |
L-serine + pyruvate | isoenzyme 1 | Mus musculus | 3-hydroxy-2-oxopropanoate + L-alanine | - |
ir | |
L-serine + pyruvate | isoenzyme 1 | Rattus norvegicus | 3-hydroxy-2-oxopropanoate + L-alanine | - |
ir | |
L-serine + pyruvate | isoenzyme 1 | Canis lupus familiaris | 3-hydroxy-2-oxopropanoate + L-alanine | - |
ir | |
L-serine + pyruvate | isoenzyme 1 | Felis catus | 3-hydroxy-2-oxopropanoate + L-alanine | - |
ir | |
L-tyrosine + glyoxylate | isoenzyme 1 | Mus musculus | 3-(4-hydroxyphenyl)-2-oxopropanoate + glycine | - |
ir | |
L-tyrosine + glyoxylate | isoenzyme 1 | Rattus norvegicus | 3-(4-hydroxyphenyl)-2-oxopropanoate + glycine | - |
ir | |
L-valine + glyoxylate | isoenzyme 1 | Mus musculus | 3-methyl-2-oxobutanoate + glycine | - |
ir | |
additional information | isoenzyme 1, little or no activity with 2-oxoglutarate as amino acceptor and alanine, serine, glutamic acid, isoleucine, methionine, glutamine, asparagine, valine, aspartic acid, leucine, phenylalanine, tyrosine, histidine, tryptophan or 5-hydroxytryptophan | Mus musculus | ? | - |
? | |
additional information | isoenzyme 1, little or no activity with 2-oxoglutarate as amino acceptor and alanine, serine, glutamic acid, isoleucine, methionine, glutamine, asparagine, valine, aspartic acid, leucine, phenylalanine, tyrosine, histidine, tryptophan or 5-hydroxytryptophan | Rattus norvegicus | ? | - |
? | |
additional information | isoenzyme 1, little or no activity with 2-oxoglutarate as amino acceptor and alanine, serine, glutamic acid, isoleucine, methionine, glutamine, asparagine, valine, aspartic acid, leucine, phenylalanine, tyrosine, histidine, tryptophan or 5-hydroxytryptophan | Canis lupus familiaris | ? | - |
? | |
additional information | isoenzyme 1, little or no activity with 2-oxoglutarate as amino acceptor and alanine, serine, glutamic acid, isoleucine, methionine, glutamine, asparagine, valine, aspartic acid, leucine, phenylalanine, tyrosine, histidine, tryptophan or 5-hydroxytryptophan | Felis catus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 38000, isoenzyme 1, SDS-PAGE | Mus musculus |
dimer | 2 * 38000, isoenzyme 1, SDS-PAGE | Rattus norvegicus |
dimer | 2 * 38000, isoenzyme 1, SDS-PAGE | Canis lupus familiaris |
dimer | 2 * 38000, isoenzyme 1, SDS-PAGE | Felis catus |
Synonyms | Comment | Organism |
---|---|---|
EC 2.6.1.51 | serine-pyruvate aminotransferase identical with liver isoenzyme 1 | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.1 | 8.4 | isoenzyme 2 | Mus musculus |
8.3 | 8.6 | - |
Mus musculus |
8.3 | 8.6 | - |
Rattus norvegicus |
8.3 | 8.6 | - |
Canis lupus familiaris |
8.3 | 8.6 | - |
Felis catus |
8.5 | 8.8 | isoenzyme 2 | Rattus norvegicus |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Mus musculus | isoelectric focusing on a pH 3.5-10 ampholine gradient | - |
5.9 |
Rattus norvegicus | isoelectric focusing on a pH 3.5-10 ampholine gradient | - |
6 |