1.8.98.6: formate:CoB-CoM heterodisulfide,ferredoxin reductase

This is an abbreviated version!
For detailed information about formate:CoB-CoM heterodisulfide,ferredoxin reductase, go to the full flat file.

Reaction

2 CO2 + 2 reduced ferredoxin [iron-sulfur] cluster +

+ 2 H+ = 2 formate + 2 oxidized ferredoxin [iron-sulfur] cluster +

Synonyms

FDH, FdhGHI, formate-driven FBEB, formate: CoMS-S-CoB oxidoreductase, HdrABC-VhuAUGD, HdrDE, HdrDE-FdhGHI, heterodisulfide reductase, heterodisulfide reductase complex, More

ECTree

1 Oxidoreductases

1.8 Acting on a sulfur group of donors

1.8.98 With other, known, physiological acceptors

1.8.98.6 formate:CoB-CoM heterodisulfide,ferredoxin reductase

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1	Activating Compound
51	AA Sequence
1	Cloned(Commentary)
5	Cofactor
8	General Information
3	Inhibitors
3	Localization
3	Metals/Ions
1	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
6	Organism
6	Pathway
3	pH Optimum
1	pH Range
3	Purification (Commentary)
1	Reaction
6	Reference
2	Source Tissue
5	Specific Activity [micromol/min/mg]
11	Substrates and Products (Substrate)
2	Subunits
11	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 1.8.98.6 - formate:CoB-CoM heterodisulfide,ferredoxin reductase

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coenzyme B,coenzyme M,ferredoxin:formate oxidoreductase

The enzyme is found in formate-oxidizing CO2-reducing methanogenic archaea such as Methanococcus maripaludis. It consists of a cytoplasmic complex of HdrABC reductase and formate dehydrogenase. Electron pairs donated by formate dehydrogenase are transferred to the HdrA subunit of the reductase, where they are bifurcated, reducing both ferredoxin and CoB-CoM heterodisulfide. cf. EC 1.8.7.3, ferredoxin:CoB-CoM heterodisulfide reductase, EC 1.8.98.4, coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase, EC 1.8.98.5, H2:CoB-CoM heterodisulfide,ferredoxin reductase, and EC 1.8.98.1, dihydromethanophenazine:CoB-CoM heterodisulfide reductase.