coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase

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2 oxidized coenzyme F420 + 2 reduced ferredoxin [iron-sulfur] cluster +

+ 2 H+ = 2 reduced coenzyme F420 + 2 oxidized ferredoxin [iron-sulfur] cluster +


hdrA2B2C2, HdrA2


     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.98 With other, known, physiological acceptors
       coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase

Systematic Name

Systematic Name on EC - coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase

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IUBMB Comments
CoB,CoM,ferredoxin:coenzyme F420 oxidoreductase
The enzyme, characterized from the archaeon Methanosarcina acetivorans, catalyses the reduction of CoB-CoM heterodisulfide back to CoB and CoM. The enzyme consists of three components, HdrA, HdrB and HdrC, all of which contain [4Fe-4S] clusters. Electrons enter at HdrA, which also contains FAD, and are transferred via HdrC to the catalytic component, HdrB. During methanogenesis from acetate the enzyme catalyses the activity of EC, ferredoxin:CoB-CoM heterodisulfide reductase. However, it can also use electron bifurcation to direct electron pairs from reduced coenzyme F420 towards the reduction of both ferredoxin and CoB-CoM heterodisulfide. This activity is proposed to take place during Fe(III)-dependent anaerobic methane oxidation. cf. EC, H2:CoB-CoM heterodisulfide,ferredoxin reductase, EC, formate:CoB-CoM heterodisulfide,ferredoxin reductase, and EC, dihydromethanophenazine:CoB-CoM heterodisulfide reductase.