1.8.98.4: coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase

This is an abbreviated version!
For detailed information about coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase, go to the full flat file.

Reaction

2 oxidized coenzyme F420 + 2 reduced ferredoxin [iron-sulfur] cluster +

+ 2 H+ = 2 reduced coenzyme F420 + 2 oxidized ferredoxin [iron-sulfur] cluster +

Synonyms

HdrA2, hdrA2B2C2

ECTree

1 Oxidoreductases

1.8 Acting on a sulfur group of donors

1.8.98 With other, known, physiological acceptors

1.8.98.4 coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase

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35	AA Sequence
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Systematic Name

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Systematic Name on EC 1.8.98.4 - coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase

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CoB,CoM,ferredoxin:coenzyme F420 oxidoreductase

The enzyme, characterized from the archaeon Methanosarcina acetivorans, catalyses the reduction of CoB-CoM heterodisulfide back to CoB and CoM. The enzyme consists of three components, HdrA, HdrB and HdrC, all of which contain [4Fe-4S] clusters. Electrons enter at HdrA, which also contains FAD, and are transferred via HdrC to the catalytic component, HdrB. During methanogenesis from acetate the enzyme catalyses the activity of EC 1.8.7.3, ferredoxin:CoB-CoM heterodisulfide reductase. However, it can also use electron bifurcation to direct electron pairs from reduced coenzyme F420 towards the reduction of both ferredoxin and CoB-CoM heterodisulfide. This activity is proposed to take place during Fe(III)-dependent anaerobic methane oxidation. cf. EC 1.8.98.5, H2:CoB-CoM heterodisulfide,ferredoxin reductase, EC 1.8.98.6, formate:CoB-CoM heterodisulfide,ferredoxin reductase, and EC 1.8.98.1, dihydromethanophenazine:CoB-CoM heterodisulfide reductase.