1.8.3.3: glutathione oxidase

This is an abbreviated version!
For detailed information about glutathione oxidase, go to the full flat file.

Reaction

2 glutathione +

Synonyms

flavin adenine dinucleotide-linked sulfhydryl oxidase, flavin-dependent sulfhydryl oxidase, flavin-linked sulfhydryl oxidase, glutathione sulfhydryl oxidase, GSH oxidase >, GSH sulfhydryl oxidase, oxidase, glutathione, protein pB119L, Sox1, sulfhydryl oxidase

ECTree

     1 Oxidoreductases

         1.8 Acting on a sulfur group of donors

             1.8.3 With oxygen as acceptor

                1.8.3.3 glutathione oxidase

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Results	in table
1	Activating Compound
1	AA Sequence
4	Application
1	CAS Registry Number
3	Cloned(Commentary)
8	Cofactor
4	Disease/ Diagnostics
2	General Stability
15	Inhibitors
5	kcat/KM [mM/s]
20	KM Value [mM]
7	Localization
3	Metals/Ions
7	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
16	Organism
2	Pathway
3	pH Optimum
4	pH Range
2	pH Stability
2	Posttranslational Modification
5	Protein Variants
4	Purification (Commentary)
1	Reaction
3	Reaction Type
16	Reference
1	Renatured (Commentary)
1	Source Tissue
1	Specific Activity [micromol/min/mg]
3	Storage Stability
48	Substrates and Products (Substrate)
8	Subunits
11	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
6	Temperature Stability [°C]
12	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 1.8.3.3 - glutathione oxidase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

2 2-mercaptoethanol + O2

(ethyldisulfanyl)ethane + H2O2

Aspergillus oryzae

Q2UA33

-

724654

-

-

?

2 D-Cys + O2

D-cystine + H2O2

Aspergillus oryzae

Q2UA33

-

724654

-

-

?

2 dithiothreitol + O2

dithiothreitol disulfide + H2O2

Aspergillus oryzae

Q2UA33

-

724654

-

-

?

2 glutathione + O2

glutathione disulfide + H2O2

Aspergillus oryzae

Q2UA33

-

724654

-

-

?

2 L-Cys + O2

L-cystine + H2O2

Aspergillus oryzae

Q2UA33

-

724654

-

-

?

2-mercaptoethanol + O2

mercaptoethanol disulfide

3 entries

cysteamine + O2

?

Penicillium sp.

-

slowly

394886

-

-

?

cysteine-glycine + O2

?

Penicillium sp.

-

enzyme immobilized on microelectrode sensor

394887

-

-

?

D-cysteine + O2

D-cystine

2 entries

dithiothreitol + cytochrome c

dithiothreitol disulfide + reduced cytochrome c

Homo sapiens

-

-

658104

-

-

?

dithiothreitol + O2

?

3 entries

dithiothreitol + O2

dithiothreitol disulfide + H2O2

2 entries

glutathione + O2

glutathione disulfide + H2O2

9 entries

L-cysteine + O2

L-cystine

4 entries

L-cysteine ethyl ester + O2

L-cystine diethyl ester

Penicillium sp.

-

low activity

394888

-

-

?

L-cysteine methyl ester + O2

L-cystine dimethyl ester

2 entries

N-acetyl-L-cysteine + O2

N,N'-diacetyl-L-cystine

3 entries

R-SH + O2

R-S-S-R + H2O2

Homo sapiens

-

-

658104

-

-

?

reduced RNase A + O2

?

2 entries

S-methylglutathione + O2

?

Penicillium sp.

-

enzyme immobilized on microelectrode sensor, low activity

394887

-

-

?

thiophenol + O2

diphenyl sulfide

Penicillium sp.

-

slowly

394886

-

-

?

additional information

?

-

5 entries

2-mercaptoethanol + O2

mercaptoethanol disulfide

Penicillium sp.

-

slowly

394886

-

-

r

2-mercaptoethanol + O2

mercaptoethanol disulfide

Penicillium sp.

-

19% of the activity with glutathione

394888

-

-

?

2-mercaptoethanol + O2

mercaptoethanol disulfide

Rattus norvegicus

-

-

394884

-

-

?

D-cysteine + O2

D-cystine

Penicillium sp.

-

slowly

394886

-

-

?

D-cysteine + O2

D-cystine

Penicillium sp.

-

low activity

394888

-

-

?

dithiothreitol + O2

?

Penicillium sp.

-

low activity

394886

-

-

?

dithiothreitol + O2

?

Penicillium sp.

-

38% of the activity with glutathione

394888

-

-

?

dithiothreitol + O2

?

Rattus norvegicus

-

-

394884

-

-

?

dithiothreitol + O2

dithiothreitol disulfide + H2O2

African swine fever virus

-

-

670095

-

-

?

dithiothreitol + O2

dithiothreitol disulfide + H2O2

Homo sapiens

-

-

658104

-

-

?

glutathione + O2

glutathione disulfide + H2O2

Aspergillus sp.

-

-

391745

-

-

?

glutathione + O2

glutathione disulfide + H2O2

Fusarium sp.

-

-

391745

-

-

?

glutathione + O2

glutathione disulfide + H2O2

Penicillium sp.

-

-

391745, 394886

-

-

?

glutathione + O2

glutathione disulfide + H2O2

Penicillium sp.

-

enzyme immobilized on microsensor

394887

-

394887

?

glutathione + O2

glutathione disulfide + H2O2

Penicillium sp.

-

enzyme immobilized on microsensor

394888

-

394888

?

glutathione + O2

glutathione disulfide + H2O2

Penicillium sp.

-

measurement of H2O2 in vivo via microelectrodes with immobilized enzyme

394888

-

394888

?

glutathione + O2

glutathione disulfide + H2O2

Penicillium sp.

-

measurement of glutathione in vivo via microelectrodes with immobilized enzyme

394887

-

394887

?

glutathione + O2

glutathione disulfide + H2O2

Penicillium sp. K-6-5

-

-

394886

-

-

?

glutathione + O2

glutathione disulfide + H2O2

Rattus norvegicus

-

-

394884

-

-

?

L-cysteine + O2

L-cystine

Penicillium sp.

-

-

394886

-

-

?

L-cysteine + O2

L-cystine

Penicillium sp.

-

low activity

394888

-

-

?

L-cysteine + O2

L-cystine

Penicillium sp. K-6-5

-

-

394886

-

-

?

L-cysteine + O2

L-cystine

Rattus norvegicus

-

-

394884

-

-

?

L-cysteine methyl ester + O2

L-cystine dimethyl ester

Penicillium sp.

-

slowly

394886

-

-

?

L-cysteine methyl ester + O2

L-cystine dimethyl ester

Penicillium sp. K-6-5

-

slowly

394886

-

-

?

N-acetyl-L-cysteine + O2

N,N'-diacetyl-L-cystine

Penicillium sp.

-

slowly

394886

-

-

?

N-acetyl-L-cysteine + O2

N,N'-diacetyl-L-cystine

Penicillium sp.

-

low activity

394888

-

-

?

N-acetyl-L-cysteine + O2

N,N'-diacetyl-L-cystine

Penicillium sp. K-6-5

-

slowly

394886

-

-

?

reduced RNase A + O2

?

Penicillium sp.

-

-

394886

-

-

?

reduced RNase A + O2

?

Rattus norvegicus

-

-

394884

-

-

?

additional information

?

-

Homo sapiens

-

ALT-2074, a catalytic mimic of glutathione oxidase, inhibits human cytochrome P450 3A isoforms in vitro

711620

-

-

?

additional information

?

-

Penicillium sp.

-

no other amio acids but D- and L-cysteine serve as substrate

394886

-

-

?

additional information

?

-

Penicillium sp.

-

D-penicilamine and coenzyme A are no substrates

394888

-

-

?

additional information

?

-

Penicillium sp. K-6-5

-

no other amio acids but D- and L-cysteine serve as substrate

394886

-

-

?

additional information

?

-

Rattus norvegicus

-

not: D,L-homocysteine

394884

-

-

?