1.5.1.54: methylenetetrahydrofolate reductase (NADH)
This is an abbreviated version!
For detailed information about methylenetetrahydrofolate reductase (NADH), go to the full flat file.
Reaction
Synonyms
5,10-CH2-H4folate reductase, 5,10-methylenetetrahydrofolate reductase, 5,10-methylenetetrahydrofolate reductase (FADH2), 5,10-methylenetetrahydrofolic acid reductase, 5,10-methylenetetrahydropteroylglutamate reductase, 5-methyltetrahydrofolate:(acceptor) oxidoreductase, metF, methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase, methylenetetrahydrofolate reductase, methylenetetrahydrofolic acid reductase, MSMEG_6596, MSMEG_6649, MTHFR1, MTHFR2, N5,10-methylenetetrahydrofolate reductase, N5,N10-methylenetetrahydrofolate reductase
ECTree
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General Information on EC 1.5.1.54 - methylenetetrahydrofolate reductase (NADH)
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
metabolism
the half-reactions proceed at rates sufficiently fast to account for overall turnover, the enzyme is kinetically competent to catalyze these oxidoreductions by a ping-pong Bi-Bi mechanism. Reoxidation of the reduced flavin by CH2-H4folate is substantially rate limiting in the physiological NADH-CH2-H4folate oxidoreductase reaction. In the NADH-menadione oxidoreductase reaction, the reduction of the flavin by NADH is rate limiting as is the reduction of flavin by CH3-H4folate in the CH3-H4folate-menadione oxidoreductase reaction
physiological function
physiological function
enzyme is able to complement a Saccharomyces cerevisiae met12 met13 double disruptant
physiological function
enzyme is able to complement a Saccharomyces cerevisiae met12 met13 double disruptant
physiological function
expression of MTHFR1 rescues an Escherichia coli MTHFR deletion mutant. The Mycolicibacterium smegmatis MTHFR1 mutant strain is partially auxotrophic for methionine and grows only poorly without methionine. The mutant strain is more sensitive to folate pathway inhibitors such as sulfachloropyridazine, 4-aminosalicylic acid, sulfamethoxazole, and trimethoprim
physiological function
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expression of MTHFR1 rescues an Escherichia coli MTHFR deletion mutant. The Mycolicibacterium smegmatis MTHFR1 mutant strain is partially auxotrophic for methionine and grows only poorly without methionine. The mutant strain is more sensitive to folate pathway inhibitors such as sulfachloropyridazine, 4-aminosalicylic acid, sulfamethoxazole, and trimethoprim
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