1.2.1.101: L-tyrosine reductase
This is an abbreviated version!
For detailed information about L-tyrosine reductase, go to the full flat file.
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Synonyms
InaA, InbA, L-tyrosine reductase LnaA, L-tyrosine reductase LnbA, L-tyrosine reductases LnaA, L-tyrosine reductases LnbA
ECTree
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Systematic Name
Systematic Name on EC 1.2.1.101 - L-tyrosine reductase
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(2S)-2-amino-3-(4-hydroxyphenyl)propanal:NADP+ oxidoreductase (ATP-forming)
The enzyme, characterized from the ascomycete fungus Aspergillus flavus, is specific for L-tyrosine. It contains three domains - an adenylation domain, a peptidyl-carrier protein (PCP) domain, and a reductase domain, and requires activation by attachment of a phosphopantetheinyl group. The enzyme activates its substrate to an adenylate form, followed by a transfer to the PCP domain. The resulting thioester is subsequently transferred to the reductase domain, where it is reduced to the aldehyde.