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Information on EC 1.2.1.101 - L-tyrosine reductase

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IUBMB Comments
The enzyme, characterized from the ascomycete fungus Aspergillus flavus, is specific for L-tyrosine. It contains three domains - an adenylation domain, a peptidyl-carrier protein (PCP) domain, and a reductase domain, and requires activation by attachment of a phosphopantetheinyl group. The enzyme activates its substrate to an adenylate form, followed by a transfer to the PCP domain. The resulting thioester is subsequently transferred to the reductase domain, where it is reduced to the aldehyde.
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The expected taxonomic range for this enzyme is: Aspergillus flavus
Synonyms
InaA, InbA, L-tyrosine reductase LnaA, L-tyrosine reductase LnbA, L-tyrosine reductases LnaA, L-tyrosine reductases LnbA, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-tyrosinal + NADP+ + AMP + diphosphate = L-tyrosine + NADPH + H+ + ATP
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