1.14.19.66: berbamunine synthase

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For detailed information about berbamunine synthase, go to the full flat file.

Reaction

Synonyms

(S)-N-methylcoclaurine oxidase (C-O phenol-coupling), (S)-N-methylcoclaurine oxidase [C-O phenol-coupling], benzyltetrahydroisoquinoline oxidase, CYP80, CYPLXXX, Cytochrome P450 80, EC 1.1.3.34, EC 1.14.21.3, oxidase, benzyltetrahydroisoquinoline

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.19 With oxidation of a pair of donors resulting in the reduction of O₂ to two molecules of water

                1.14.19.66 berbamunine synthase

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Results	in table
2	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
1	Cofactor
1	KM Value [mM]
3	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
3	Organism
3	Pathway
2	pH Optimum
3	Purification (Commentary)
2	Reaction
3	Reaction Type
3	Reference
2	Source Tissue
2	Specific Activity [micromol/min/mg]
6	Substrates and Products (Substrate)
3	Subunits
9	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
3	Temperature Range [°C]
2	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.14.19.66 - berbamunine synthase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

2 (S)-N-methylcoclaurine + 2 (R)-N-methylcoclaurine + [reduced NADPH-hemoprotein reductase] + O2

berbamunine + guattegaumerine + [oxidized NADPH-hemoprotein reductase] + H2O

Berberis stolonifera

P47195

enzyme mediates highly regiospecific and stereospecific oxidative phenol coupling to afford natural bisbenzylisoquinoline alkaloids

393212

-

393212

?