1.14.19.53: all-trans-retinol 3,4-desaturase
This is an abbreviated version!
For detailed information about all-trans-retinol 3,4-desaturase, go to the full flat file.
Word Map on EC 1.14.19.53
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1.14.19.53
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retinal
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chromophore
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red-shifted
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photoreceptors
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retinoids
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desaturation
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epithelium
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zebrafish
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tuning
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opsin
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aquatic
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orphan
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vision
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habitats
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cone
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long-wavelength
- 1.14.19.53
- retinal
- chromophore
-
red-shifted
-
photoreceptors
-
retinoids
-
desaturation
- epithelium
- zebrafish
-
tuning
- opsin
-
aquatic
-
orphan
-
vision
-
habitats
-
cone
-
long-wavelength
Reaction
+ 2 reduced adrenodoxin + 2 H+ + = + 2 oxidized adrenodoxin + 2 H2O
Synonyms
CYP27C1, cytochrome P450 27C1
ECTree
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Substrates Products
Substrates Products on EC 1.14.19.53 - all-trans-retinol 3,4-desaturase
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REACTION DIAGRAM
all-trans-retinal + 2 reduced adrenodoxin + 2 H+ + O2
all-trans-3,4-didehydroretinal + 2 oxidized adrenodoxin + 2 H2O
all-trans-retinoic acid + 2 reduced adrenodoxin + 2 H+ + O2
all-trans-3,4-didehydroretinoic acid + 2 oxidized adrenodoxin + 2 H2O
all-trans-retinol + 2 reduced adrenodoxin + 2 H+ + O2
all-trans-3,4-didehydroretinol + 2 oxidized adrenodoxin + 2 H2O
all-trans-3,4-didehydroretinal + 2 oxidized adrenodoxin + 2 H2O
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all-trans-retinal + 2 reduced adrenodoxin + 2 H+ + O2
all-trans-3,4-didehydroretinal + 2 oxidized adrenodoxin + 2 H2O
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?
all-trans-3,4-didehydroretinoic acid + 2 oxidized adrenodoxin + 2 H2O
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-
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?
all-trans-retinoic acid + 2 reduced adrenodoxin + 2 H+ + O2
all-trans-3,4-didehydroretinoic acid + 2 oxidized adrenodoxin + 2 H2O
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-
-
?
all-trans-3,4-didehydroretinol + 2 oxidized adrenodoxin + 2 H2O
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-
-
?
all-trans-retinol + 2 reduced adrenodoxin + 2 H+ + O2
all-trans-3,4-didehydroretinol + 2 oxidized adrenodoxin + 2 H2O
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-
-
?
all-trans-retinol + 2 reduced adrenodoxin + 2 H+ + O2
all-trans-3,4-didehydroretinol + 2 oxidized adrenodoxin + 2 H2O
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kinetic isotope effects of 1.52.3 (on kcat/Km) are observed with 3,3-, 4,4-, and 3,3,4,4-deuterated retinol. Deuteration at C-4 produces a 4fold increase in 3-hydroxylation due to metabolic switching, with no observable effect on 4-hydroxylation. Deuteration at C-3 produces a strong kinetic isotope effect for 3-hydroxylation but not 4-hydroxylation
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additional information
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kinetic isotope effects of 1.52.3 (on kcat/Km) are observed with 3,3-, 4,4-, and 3,3,4,4-deuterated retinol. Deuteration at C-4 produces a 4fold increase in 3-hydroxylation due to metabolic switching, with no observable effect on 4-hydroxylation. Deuteration at C-3 produces a strong kinetic isotope effect for 3-hydroxylation but not 4-hydroxylation
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