1.14.19.53: all-trans-retinol 3,4-desaturase
This is an abbreviated version!
For detailed information about all-trans-retinol 3,4-desaturase, go to the full flat file.
Word Map on EC 1.14.19.53
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1.14.19.53
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retinal
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chromophore
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red-shifted
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photoreceptors
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retinoids
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desaturation
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epithelium
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zebrafish
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tuning
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opsin
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aquatic
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orphan
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vision
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habitats
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cone
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long-wavelength
- 1.14.19.53
- retinal
- chromophore
-
red-shifted
-
photoreceptors
-
retinoids
-
desaturation
- epithelium
- zebrafish
-
tuning
- opsin
-
aquatic
-
orphan
-
vision
-
habitats
-
cone
-
long-wavelength
Reaction
+ 2 reduced adrenodoxin + 2 H+ + = + 2 oxidized adrenodoxin + 2 H2O
Synonyms
CYP27C1, cytochrome P450 27C1
ECTree
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General Information
General Information on EC 1.14.19.53 - all-trans-retinol 3,4-desaturase
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physiological function
knockout of Cyp27c1 in zebrafish abrogates production of vitamin A2, eliminates the animal's ability to red-shift its photoreceptor spectral sensitivity, and reduces its ability to see and respond to near-infrared light
physiological function
the most likely catalytic mechanism begins with abstraction of a hydrogen atom from C-4 (or possibly C-3) initiating the desaturation pathway, followed by a sequential abstraction of a hydrogen atom or proton-coupled electron transfer. Adrenodoxin reduction and hydrogen abstraction both contribute to rate limitation