1.14.11.73: [protein]-arginine 3-hydroxylase

This is an abbreviated version!
For detailed information about [protein]-arginine 3-hydroxylase, go to the full flat file.

Reaction

[protein]-L-arginine
+
2-oxoglutarate
+
O2
=
[protein]-(3R)-3-hydroxy-L-arginine
+
succinate
+
CO2

Synonyms

JMJD5, KDM8

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.73 [protein]-arginine 3-hydroxylase

Substrates Products

Substrates Products on EC 1.14.11.73 - [protein]-arginine 3-hydroxylase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
[RCCD1]-L-arginine + 2-oxoglutarate + O2
[RCCD1]-(3R)-3-hydroxy-L-arginine + succinate + CO2
show the reaction diagram
substrate i.e. regulator of chromosome condensation domain-containing protein 1
-
0
?
[RPS6]-L-arginine + 2-oxoglutarate + O2
[RPS6]-(3R)-3-hydroxy-L-arginine + succinate + CO2
show the reaction diagram
substrate i.e. ribosomal protein S6
-
0
?
additional information
?
-
JMJD5 catalyses stereoselective C-3 hydroxylation of arginine residues in sequences from human regulator of chromosome condensation domain-containing protein 1 (RCCD1) and ribosomal protein S6 (RPS6)
-
0
-