1.13.12.4: lactate 2-monooxygenase

This is an abbreviated version!
For detailed information about lactate 2-monooxygenase, go to the full flat file.

Word Map on EC 1.13.12.4

Reaction

(S)-lactate
+
O2
=
acetate
+
CO2
+
H2O

Synonyms

L-lactate monooxygenase, L-lactate-2-monooxygenase, lactate monooxygenase, lactate oxidase, lactate oxidative decarboxylase, lactate oxygenase, lactic oxidase, lactic oxygenase

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
                1.13.12.4 lactate 2-monooxygenase

Engineering

Engineering on EC 1.13.12.4 - lactate 2-monooxygenase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
G99A
-
(S)-lactate binds tighter to the G99A-mutant than to wild-type
H290Q
K266M
-
the rate of reduction with (S)-lactate is decreased compared with that of the wild-type enzyme, the mutant enzyme is virtually inactive
R293K
-
uncoupled reaction, no decarboxylation
Y152F
-
nearly as active as wild-type
Y44F
-
uncoupled reaction, no decarboxylation