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1.13.12.4: lactate 2-monooxygenase

This is an abbreviated version!
For detailed information about lactate 2-monooxygenase, go to the full flat file.

Word Map on EC 1.13.12.4

Reaction

(S)-lactate
+
O2
=
acetate
 +
CO2
 +
H2O

Synonyms

L-lactate monooxygenase, L-lactate-2-monooxygenase, lactate monooxygenase, lactate oxidase, lactate oxidative decarboxylase, lactate oxygenase, lactic oxidase, lactic oxygenase, LMO

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
                1.13.12.4 lactate 2-monooxygenase

Reference

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Reference on EC 1.13.12.4 - lactate 2-monooxygenase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Flashner, M.S.; Massey, V.
Flavoprotein oxygenases
Mol. Mech. Oxygen Activ. (Hayaishi, O., ed.) Academic Press, New York
245-283
1974
Mycolicibacterium phlei, Mycolicibacterium smegmatis
-
Manually annotated by BRENDA team
Sun, W.; Williams, C.H., Jr.; Massey, V.
Site-directed mutagenesis of glycine 99 to alanine in L-lactate monooxygenase from Mycobacterium smegmatis
J. Biol. Chem.
271
17226-17233
1996
Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Muh, U.; Massey, V.; Williams, C.H., Jr.
Lactate Monooxygenase. I. Expression of the mycobacterial gene in Escherichia coli and site-directed mutagenesis of lysine 266
J. Biol. Chem.
269
7982-7988
1994
Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Muh, U.; Williams, C.H., Jr.; Massey, V.
Lactate monooxygenase. II. Site-directed mutagenesis of the postulated active site base histidine 290
J. Biol. Chem.
269
7989-7993
1994
Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Giegel, D.A.; Williams, C.H.; Massey, V.
L-Lactate 2-monooxygenase from Mycobacterium smegmatis. Cloning, nucleotide sequence, and primary structure homology within an enzyme family
J. Biol. Chem.
265
6626-6632
1990
Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Murphy, C.J.; Shepherd, M.G.; Sullivan, P.A.
Chemical modification of L-lactate 2-monooxygenase with fluorodinitrobenzene: evidence for two essential histidine residues
Biochemistry
22
1665-1669
1983
Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Durfor, C.N.; Cromartie, T.H.
Inactivation of L-lactate monooxygenase by nitration with tetranitromethane
Arch. Biochem. Biophys.
210
710-716
1981
Mycolicibacterium phlei
Manually annotated by BRENDA team
Choong, Y.S.; Massey, V.
Studies on lactate oxidase substituted with synthetic flavins. Iso-FMN lactate oxidase
J. Biol. Chem.
256
8671-8678
1981
Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Peters, R.G.; Jones, W.C.; Cromartie, T.H.
Inactivation of L-lactate monooxygenase with 2,3-butanedione and phenylglyoxal
Biochemistry
20
2564-2571
1981
Mycolicibacterium phlei
Manually annotated by BRENDA team
Soon, C.Y.; Sheperd, M.G.; Sullivan, P.A.
Inactivation and modification of lactate oxidase with fluorodinitrobenzene
Biochem. J.
173
255-262
1978
Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Soon, C.Y.; Sheperd, M.G.; Sullivan, P.A.
Modification of lactate oxidase with diethyl pyrocarbonate. Evidence for an active-site histidine residue
Biochem. J.
165
385-393
1977
Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Sullivan, P.A.; Soon, C.Y.; Schreurs, W.J.; Cutfield, J.F.; Sheperd, M.G.
The structure of L-lactate oxidase from Mycobacterium smegmatis
Biochem. J.
165
375-383
1977
Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Ghisla, S.; Massey, V.
Studies on the mechanism of action of the flavoenzyme lactate oxidase. Proton uptake and release during the binding of transition state analogs
J. Biol. Chem.
252
6729-6735
1977
Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Ghisla, S.; Ogata, H.; Massey, V.; Schonbrunn, A.; Abeles, R.H.; Walsh, C.T.
Kinetic studies on the inactivation of L-lactate oxidase by [the acetylenic suicide substrate] 2-hydroxy-3-butynoate
Biochemistry
15
1791-1797
1976
Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Takemori, S.; Katagiri, M.
Lactate oxygenase of Mycobacterium phlei
Methods Enzymol.
41B
329-333
1975
Mycolicibacterium phlei
-
Manually annotated by BRENDA team
Ghisla, S.; Massey, V.
Mechanism of inactivation of the flavoenzyme lactate oxidase by oxalate
J. Biol. Chem.
250
577-584
1975
Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Averill, B.A.; Schonbrunn, A.; Abeles, R.H.; Weinstock, L.T.; Cheng, C.C.; Fisher, J.; Spencer, R.; Walsh, C.
Studies on the mechanism of Mycobacterium smegmatis L-lactate oxidase. 5-Deazaflavin mononucleotide as a coenzyme analogue
J. Biol. Chem.
250
1603-1605
1975
Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Takemori, S.; Tajima, H.; Kawahara, F.; Nakai, Y.; Katagiri, M.
A lactate oxygenase from Mycobacterium phlei. 3. Evidence for the subunit structure
Arch. Biochem. Biophys.
160
289-303
1974
Mycolicibacterium phlei
Manually annotated by BRENDA team
Takemori, S.; Nakai, Y.; Nakazawa, K.; Katagiri, M.
A lactate oxygenase from Mycobacterium phlei. II. Spectral characteristics in aerobic and anaerobic reactions
Arch. Biochem. Biophys.
154
137-146
1973
Mycolicibacterium phlei
Manually annotated by BRENDA team
Walsh, C.; Lockridge, O.; Massey, V.; Abeles, R.
Studies on the mechanism of action of the flavoenzyme lactate oxidase. Oxidation and elimination with beta-chlorolactate
J. Biol. Chem.
248
7049-7054
1973
Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Lockridge, O.; Massey, V.; Sullivan, P.A.
Mechanism of action of the flavoenzyme lactate oxidase
J. Biol. Chem.
247
8097-8106
1972
Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Walsh, C.T.; Schonbrunn, A.; Lockridge, O.; Massey, V.; Abeles, R.H.
Inactivation of a flavoprotein, lactate oxidase, by an acetylenic substrate
J. Biol. Chem.
247
6004-6006
1972
Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Sutton, W.B.
Mechanism of action and crytallization of lactic oxidative decarboxylase from Mycobacterium phlei
J. Biol. Chem.
226
395-405
1957
Mycolicibacterium phlei
Manually annotated by BRENDA team
Muh, U.; Williams, C.H., Jr.; Massey, V.
Lactate monooxygenase. III. Additive contributions of active site residues to catalytic efficiency and stabilization of an anionic transition state
J. Biol. Chem.
269
7994-8000
1994
Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Choong, Y.S.; Shepherd, M.G.; Sullivan, P.A.
Preparation of the lactate oxidase apoenzyme and studies on the binding of flavin mononucleotide to the apoenzyme
Biochem. J.
145
37-45
1975
Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Kean, K.M.; Karplus, P.A.
Structure and role for active site lid of lactate monooxygenase from Mycobacterium smegmatis
Protein Sci.
28
135-149
2019
Mycolicibacterium smegmatis (P21795), Mycolicibacterium smegmatis
Manually annotated by BRENDA team