1.11.2.6: L-tyrosine peroxygenase

This is an abbreviated version!
For detailed information about L-tyrosine peroxygenase, go to the full flat file.

Word Map on EC 1.11.2.6

Reaction

L-tyrosine
+
H2O2
=
L-Dopa
+
H2O

Synonyms

L-tyrosine 3-hydroxylase, LmbB2, Orf13, TyrH

ECTree

     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.2 Peroxygenases
                1.11.2.6 L-tyrosine peroxygenase

Systematic Name

Systematic Name on EC 1.11.2.6 - L-tyrosine peroxygenase

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SYSTEMATIC NAME
IUBMB Comments
L-tyrosine:hydrogen-peroxide oxidoreductase (L-dopa-forming)
The enzyme from the bacterium Streptomyces lincolnensis participates in the biosynthesis of the antibiotic lincomycin A, while that from Streptomyces refuineus is involved in anthramycin biosynthesis. The enzyme, which contains a heme b cofactor, is rapidly inactivated in the presence of hydrogen peroxide, but the presence of L-tyrosine protects it. cf. EC 1.11.2.5, 3-methyl-L-tyrosine peroxygenase.