1.1.1.366: L-idonate 5-dehydrogenase (NAD+)
This is an abbreviated version!
For detailed information about L-idonate 5-dehydrogenase (NAD+), go to the full flat file.
Reaction
Synonyms
GluE, L-IdnDH, L-idonate 5-dehydrogenase, L-idonate dehydrogenase, LidnDH, NAD+ requiring L-idonate 5-dehydrogenase
ECTree
1.1.1.366 L-idonate 5-dehydrogenase (NAD+)Advanced search results
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General Information on EC 1.1.1.366 - L-idonate 5-dehydrogenase (NAD+)
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
malfunction
metabolism
physiological function
enzyme LidnDH catalyzes the conversion of L-idonate to 5-keto D-gluconic acid in plant and is proposed to be a rate-limiting step in biosynthesis of tartaric acid from ascorbic acid
additional information
cultivar Cabernet Sauvignon transcriptome analysis dependent on regional parameters of six different samples, overview. Two unigenes encoding L-idonate dehydrogenase (LidnDH) are detected from the assembled transcriptome. One is expressed higher in Changli region berries than in Gaotai region berries at E-L 31 stage,while the other is expressed higher at E-L 38 stage in Gaotai region berries
malfunction
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gluD deletion results in accumulation of 2-keto-L-gulonate in the liquid cultivation, while the gluE deletion results in reduced growth and cessation of the D-glucuronic acid catabolism
malfunction
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gluD deletion results in accumulation of 2-keto-L-gulonate in the liquid cultivation, while the gluE deletion results in reduced growth and cessation of the D-glucuronic acid catabolism
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malfunction
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gluD deletion results in accumulation of 2-keto-L-gulonate in the liquid cultivation, while the gluE deletion results in reduced growth and cessation of the D-glucuronic acid catabolism
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metabolism
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in the filamentous fungus Aspergillus niger, the enzymes that are known to be part of the D-glucuronic acid catabolism pathway are the NADPH requiring D-glucuronic acid reductase forming L-gulonate and the NADH requiring 2-keto-L-gulonate reductase that forms L-idonate. With the aid of RNA sequencing two more enzymes of the pathway are identified. The first is a NADPH requiring 2-keto-L-gulonate reductase that forms L-idonate, GluD (EC 1.1.1.264). The second is a NAD+ requiring L-idonate 5-dehydrogenase forming 5-keto-gluconate, GluE. The genes coding for these two enzymes are clustered and share the same bidirectional promoter
metabolism
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in the filamentous fungus Aspergillus niger, the enzymes that are known to be part of the D-glucuronic acid catabolism pathway are the NADPH requiring D-glucuronic acid reductase forming L-gulonate and the NADH requiring 2-keto-L-gulonate reductase that forms L-idonate. With the aid of RNA sequencing two more enzymes of the pathway are identified. The first is a NADPH requiring 2-keto-L-gulonate reductase that forms L-idonate, GluD (EC 1.1.1.264). The second is a NAD+ requiring L-idonate 5-dehydrogenase forming 5-keto-gluconate, GluE. The genes coding for these two enzymes are clustered and share the same bidirectional promoter
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metabolism
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in the filamentous fungus Aspergillus niger, the enzymes that are known to be part of the D-glucuronic acid catabolism pathway are the NADPH requiring D-glucuronic acid reductase forming L-gulonate and the NADH requiring 2-keto-L-gulonate reductase that forms L-idonate. With the aid of RNA sequencing two more enzymes of the pathway are identified. The first is a NADPH requiring 2-keto-L-gulonate reductase that forms L-idonate, GluD (EC 1.1.1.264). The second is a NAD+ requiring L-idonate 5-dehydrogenase forming 5-keto-gluconate, GluE. The genes coding for these two enzymes are clustered and share the same bidirectional promoter
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