1.1.1.337: L-2-hydroxycarboxylate dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about L-2-hydroxycarboxylate dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.1.1.337

Reaction

a (2S)-2-hydroxycarboxylate
+
NAD+
=
a 2-oxocarboxylate
+
NADH
+
H+

Synonyms

(R)-sulfolactate dehydrogenase, ComC, L-2-hydroxyacid dehydrogenase, L-2-hydroxyacid dehydrogenase (NAD+), L-2-hydroxyisocaproate dehydrogenase, L-HicDH, L-hydroxyisocaproate dehydrogenase, L-sulfolactate dehydrogenase, MDH I, MJ1425, sulfolactate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.337 L-2-hydroxycarboxylate dehydrogenase (NAD+)

Inhibitors

Inhibitors on EC 1.1.1.337 - L-2-hydroxycarboxylate dehydrogenase (NAD+)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
10 mM, 15% inhibition
4-chloromercuribenzoate
weak inhibition
iodoacetamide
weak inhibition
iodoacetate
weak inhibition
KCN
weak inhibition
NADH
inhibition above 0.24 mM
additional information
reduced glutathione (20 mM) has no effect. EDTA, 2,2'-bipyridyl in 1 mM and 10 mM final concentrations have no effect on enzymatic activity
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