1.1.1.337: L-2-hydroxycarboxylate dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about L-2-hydroxycarboxylate dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.1.1.337

Reaction

a (2S)-2-hydroxycarboxylate
+
NAD+
=
a 2-oxocarboxylate
+
NADH
+
H+

Synonyms

(R)-sulfolactate dehydrogenase, ComC, L-2-hydroxyacid dehydrogenase, L-2-hydroxyacid dehydrogenase (NAD+), L-2-hydroxyisocaproate dehydrogenase, L-HicDH, L-hydroxyisocaproate dehydrogenase, L-sulfolactate dehydrogenase, MDH I, MJ1425, sulfolactate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.337 L-2-hydroxycarboxylate dehydrogenase (NAD+)

Substrates Products

Substrates Products on EC 1.1.1.337 - L-2-hydroxycarboxylate dehydrogenase (NAD+)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2R)-3-sulfolactate + NAD+
3-sulfopyruvate + NADH + H+
show the reaction diagram
(S)-2-hydroxyglutarate + NAD+
2-oxoglutarate + NADH + H+
show the reaction diagram
-
-
-
r
(S)-lactate + NAD+
pyruvate + NADH + H+
show the reaction diagram
1-hydroxy-1,3,4,6-hexanetetracarboxylate + NAD+
1-oxo-1,3,4,6-hexanetetracarboxylate + NADH + H+
show the reaction diagram
-
-
-
r
2-hydroxycaproate + NAD+
2-oxocaproate + NADH + H+
show the reaction diagram
-
-
-
r
2-hydroxyisocaproate + NAD+
2-oxoisocaproate + NADH + H+
show the reaction diagram
the initial rate of the reduction of 2-oxoisocaproate is about seven times faster than the reverse reaction, the dehydrogenation of L-2-hydroxyisocaproate, measured in buffers at the respective pH optima
-
-
r
2-hydroxyisovalerate + NAD+
2-oxoisovalerate + NADH + H+
show the reaction diagram
-
-
-
r
2-hydroxyoctanoate + NAD+
2-oxooctanoate + NADH + H+
show the reaction diagram
-
-
-
?
2-hydroxyvalerate + NAD+
2-oxovalerate + NADH + H+
show the reaction diagram
-
-
-
r
2-oxobutyrate + NADH + H+
2-hydroxybutyrate + NAD+
show the reaction diagram
-
-
-
r
2-oxocaproate + NADH + H+
2-hydroxycaproate + NAD+
show the reaction diagram
2-oxoglutarate + NADH + H+
(S)-2-hydroxyglutarate + NAD+
show the reaction diagram
-
-
-
-
?
2-oxoisocaproate + NADH + H+
2-hydroxyisocaproate + NAD+
show the reaction diagram
2-oxoisovalerate + NADH + H+
2-hydroxyisovalerate + NAD+
show the reaction diagram
-
-
-
r
2-oxooctanoate + NADH + H+
2-hydroxyoctanoate + NAD+
show the reaction diagram
-
-
-
r
2-oxopentanedioic acid + NADH + H+
2-hydroxypentandioic acid + NAD+
show the reaction diagram
-
-
-
-
?
2-oxovalerate + NADH + H+
2-hydroxyvalerate + NAD+
show the reaction diagram
-
-
-
r
3-phenyllactate + NAD+
pyruvate + NADH + H+
show the reaction diagram
-
-
-
r
3-sulfopyruvate + NADH + H+
(S)-3-sulfolactate + NAD+
show the reaction diagram
3-sulfopyruvate + NADH + H+
3-sulfolactate + NAD+
show the reaction diagram
4-methyl-2-oxopentanoate + NADH + H+
(S)-2-hydroxy-4-methylpentanoate + NAD+
show the reaction diagram
-
-
-
-
r
a 2-oxocarboxylate + NADH + H+
(2S)-2-hydroxycarboxylate + NAD+
show the reaction diagram
glyoxylate + NADH + H+
2-hydroxypropanoate + NAD+
show the reaction diagram
-
-
-
-
?
L-lactate + NAD+
pyruvate + NADH + H+
show the reaction diagram
-
-
-
r
oxaloacetate + NADH + H+
(S)-malate + NAD+
show the reaction diagram
oxaloacetate + NADH + H+
malate + NAD+
show the reaction diagram
-
-
-
-
?
oxo-tert-leucine + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
oxopropandioic acid + NADH + H+
2-hydroxypropanedioic acid + NAD+
show the reaction diagram
-
-
-
-
?
phenylglyoxylate + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
phenylpyruvate + NADH + H+
3-phenyllactate + NAD+
show the reaction diagram
pyruvate + NADH + H+
(S)-lactate + NAD+
show the reaction diagram
-
-
-
-
?
pyruvate + NADH + H+
L-lactate + NAD+
show the reaction diagram
additional information
?
-