1.1.1.148: estradiol 17alpha-dehydrogenase
This is an abbreviated version!
For detailed information about estradiol 17alpha-dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.148
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1.1.1.148
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testosterone
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epitestosterone
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steroid-binding
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aldo-keto
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3alpha-hsd
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dehydrogenases
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delta4
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3-glucuronide
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oestrogen
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1.1.1.62
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nadph-enzyme
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deae-cellulose
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particularities
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nadp+
- 1.1.1.148
- testosterone
- epitestosterone
-
steroid-binding
-
aldo-keto
- 3alpha-hsd
- dehydrogenases
-
delta4
- 3-glucuronide
- oestrogen
-
1.1.1.62
-
nadph-enzyme
- deae-cellulose
-
particularities
- nadp+
Reaction
Synonyms
17alpha-estradiol dehydrogenase, 17alpha-HSD, 17alpha-hydroxy steroid dehydrogenase, 17alpha-hydroxy steroid oxidoreductase, 17alpha-hydroxysteroid dehydrogenase, 17alpha-hydroxysteroid oxidoreductase, estradiol 17alpha-oxidoreductase, More
ECTree
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Substrates Products
Substrates Products on EC 1.1.1.148 - estradiol 17alpha-dehydrogenase
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REACTION DIAGRAM
17beta-hydroxy-4-androsten-3-one + NADP+
4-androsten-3,17-dione + NADPH
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testosterone
-
-
?
5alpha-androstan-3beta,17alpha-diol + NADP+
3beta-hydroxy-5alpha-androstan-17-one + NADPH
-
-
-
-
?
5alpha-dihydrotestosterone + NADPH
5alpha-androstane-3alpha,17alpha-diol + NADP+
-
-
-
?
5alpha-pregnane-3,20-dione + NADPH + H+
3alpha,5alpha-3-hydroxypregnan-20-one + NADP+
-
-
-
?
androstanedione + NADPH
5alpha-androstane-3-one-17alpha-ol + NADP+
-
-
-
?
androsterone + NADPH
5alpha-androstane-3alpha,17alpha-diol + NADP+
-
-
-
?
dehydroepiandrosterone + NADPH
5-androstene-3alpha,17alpha-diol + NADP+
-
-
-
?
estradiol-17alpha 3-galacturonide + NADP+
estrone 3-galacturonide + NADPH
-
-
-
-
?
estradiol-17alpha 3-glucoside + NADP+
estrone 3-glucoside + NADPH
-
-
-
-
?
4-androsten-3,17-dione + NADPH
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epitestosterone
-
-
r
17alpha-hydroxy-4-androsten-3-one + NADP+
4-androsten-3,17-dione + NADPH
-
epitestosterone
-
-
r
17alpha-hydroxy-4-androsten-3-one + NADP+
4-androsten-3,17-dione + NADPH
-
epitestosterone
-
-
r
17alpha-hydroxy-4-androsten-3-one + NADP+
4-androsten-3,17-dione + NADPH
-
epitestosterone
-
-
r
estrone 3-glucuronide + NADPH
-
-
-
-
?
estradiol-17alpha 3-glucuronide + NADP+
estrone 3-glucuronide + NADPH
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isoform IC is more specific for this substrate than for 17alpha-estradiol
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-
?
?
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the enzyme is involved in the biosynthesis of epitestosterone, the 17alpha-epimer of testosterone
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-
?
additional information
?
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the enzyme is involved in the biosynthesis of epitestosterone, the 17alpha-epimer of testosterone
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-
?
additional information
?
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substrate specificity of the recombinant enzyme, overview
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-
?
additional information
?
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-
substrate specificity of the recombinant enzyme, overview
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-
?