EC Number |
IC50 Value |
IC50 Value Maximum |
Inhibitor |
Reference |
---|
1.4.3.4 | -999 |
- |
more |
above 1.0 mM for 1-(3,5-diethoxypyridin-4-yl)methanamine dihydrochloride, 3,3'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dipropan-1-ol dihydrochloride, 4,4'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dibutan-1-ol dihydrochloride, 1-[3,5-bis(ethylsulfanyl)pyridin-4-yl]methanamine dihydrochloride, 1-[3,5-bis(tert-butylsulfanyl)pyridin-4-yl]methanamine dihydrochloride, and above 0.17 mM for 4-(aminomethyl)-N-methylpyridine-3,5-diamine dihydrochloride, 3-methylamino-4-aminomethylpyridine dihydrochloride, and 3-ethylamino-4-aminomethylpyridine dihydrochloride. Above 2.0 mM for 3-amino-4-aminomethylpyridine dihydrochloride and above 0.1 mM for 3-cyclopentylamino-4-aminomethylpyridine dihydrochloride hemihydrate, 3-cyclohexylamino-4-aminomethylpyridine dihydrochloride monohydrate, 3-cycloheptylamino-4-aminomethylpyridine dihydrochloride monohydrate, 3-(1-piperidinyl)-4-aminomethylpyridine dihydrochloride hemihydrate, 2-methylaminobenzylamine dihydrochloride, and 2-ethylaminobenzylamine dihydrochloride |
675286 |
1.4.3.4 | -999 |
- |
more |
above 1.6 mM for 1-(3,5-diethoxypyridin-4-yl)methanamine dihydrochloride, 3,3'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dipropan-1-ol dihydrochloride, and above 2.0 mM for 3-amino-4-aminomethylpyridine dihydrochloride. Above 0.1 mM for 3-cyclopropylamino-4-aminomethylpyridine dihydrochloride sesquihydrate, 3-cyclopentylamino-4-aminomethylpyridine dihydrochloride hemihydrate, 3-cyclohexylamino-4-aminomethylpyridine dihydrochloride monohydrate, and 3-(1-piperidinyl)-4-aminomethylpyridine dihydrochloride hemihydrate |
675286 |
1.4.3.4 | -999 |
- |
more |
inhibition kinetics |
706847 |
1.4.3.4 | -999 |
- |
more |
pIC50 value of rosiridin for MAO B inhibition is 5.38, the pIC50 value for L-deprenyl is 7.23 for MAO B inhibition |
704855 |
1.4.3.4 | 0.000000386 |
- |
N-(3,4-dichlorophenyl)-1-methyl-1H-indazole-5-carboxamide |
isoform MAO-B, at pH 7.4, temperature not specified in the publication |
742443 |
1.4.3.4 | 0.000000586 |
- |
N-(3,4-dichlorophenyl)-1H-indazole-5-carboxamide |
isoform MAO-B, at pH 7.4, temperature not specified in the publication |
742443 |
1.4.3.4 | 0.000000679 |
- |
N-(3-chloro-4-fluorophenyl)-1H-indazole-5-carboxamide |
isoform MAO-B, at pH 7.4, temperature not specified in the publication |
742443 |
1.4.3.4 | 0.00000108 |
- |
N-(3,4-dichlorophenyl)-1-(2-methoxyethyl)-1H-indazole-5-carboxamide |
isoform MAO-B, at pH 7.4, temperature not specified in the publication |
742443 |
1.4.3.4 | 0.0000012 |
- |
Clorgyline |
IC50: 1.2 nM |
656047 |
1.4.3.4 | 0.00000132 |
- |
N-(3,4-dichlorophenyl)-1-methyl-1H-indazole-5-carboxamide |
isoform MAO-B, at pH 7.4, temperature not specified in the publication |
742443 |