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Literature summary for 1.4.3.4 extracted from

  • Saidemberg, D.M.; Ferreira, M.A.; Takahashi, T.N.; Gomes, P.C.; Cesar-Tognoli, L.M.; da Silva-Filho, L.C.; Tormena, C.F.; da Silva, G.V.; Palma, M.S.
    Monoamine oxidase inhibitory activities of indolylalkaloid toxins from the venom of the colonial spider Parawixia bistriata: functional characterization of PwTX-I (2009), Toxicon, 54, 717-724.
    View publication on PubMed
Search for more literature for 1.4.3.4

Inhibitors

Inhibitors Comment Organism Structure
(+/-)-6-hydroxytrypargine an indolylalkaloid toxin enzyme inhibitor from the venom of the colonial spider Parawixia bistriata, synthesized by reaction of 5-hydroxytryptamine hydrochloride with N-(3-[1,3]dioxolan-2-yl-propyl)-guanidine sulfate, overview Homo sapiens
1-(4-guanidinobutoxy)-6-hydroxy-1,2,3,4-tetrahydro-beta-carboline an indolylalkaloid toxin enzyme inhibitor from the venom of the colonial spider Parawixia bistriata Homo sapiens
1-guanidino-6-hydroxy-3,5-dihydro-beta-carboline an indolylalkaloid toxin enzyme inhibitor from the venom of the colonial spider Parawixia bistriata Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetics Homo sapiens
0.0165
-
 kynuramine pH 7.4, 37°C, MAO-B Homo sapiens
0.0652
-
 kynuramine pH 7.4, 37°C, MAO-A Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation MAO-A and MAO-B Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
kynuramine + H2O + O2
-
 Homo sapiens 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
 ?
serotonin + H2O + O2
-
 Homo sapiens (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
MAO-A
-
 Homo sapiens
MAO-B
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
flavin
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
 inhibition kinetics Homo sapiens additional information
0.008
-
 pH 7.4, 37°C, MAO-B Homo sapiens (-)-6-hydroxytrypargine
0.015
-
 pH 7.4, 37°C, MAO-B Homo sapiens (+)-6-hydroxytrypargine
0.034
-
 pH 7.4, 37°C, MAO-A Homo sapiens (-)-6-hydroxytrypargine
0.039
-
 pH 7.4, 37°C, MAO-A Homo sapiens (+)-6-hydroxytrypargine