Application | Comment | Organism |
---|---|---|
medicine | Rhodiola rosea roots have potent antidepressant activity by inhibiting MAO A and may also find application in the control of senile dementia by their inhibition of MAO B | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cinnamyl alcohol | compound from Rhodiola rosea extract, inhibits both MAO A and MAO B | Homo sapiens | |
Clorgyline | inhibition of MAO A and MAO B | Homo sapiens | |
epigallocatechin gallate dimer | compound from Rhodiola rosea extract, inhibits both MAO A and MAO B | Homo sapiens | |
L-deprenyl | inhibition of MAO A and MAO B | Homo sapiens | |
additional information | Rhodiola rosea roots have potent antidepressant activity by inhibiting MAO A and may also find application in the control of senile dementia by their inhibition of MAO B, no inhibition of both isozymes by rosavin, rosarin, and rosin | Homo sapiens | |
rhodiocyanoside A | compound from Rhodiola rosea extract, inhibits MAO B, not MAO A | Homo sapiens | |
rhodioloside B | compound from Rhodiola rosea extract, inhibits MAO B, not MAO A | Homo sapiens | |
rosiridin | compound from Rhodiola rosea extract, inhibits both MAO A and MAO B | Homo sapiens | |
salidroside | compound from Rhodiola rosea extract, inhibits MAO B, not MAO A | Homo sapiens | |
triandrin | compound from Rhodiola rosea extract, inhibits MAO B, not MAO A | Homo sapiens | |
tyrosol | compound from Rhodiola rosea extract, inhibits MAO B, not MAO A | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P27338 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
kynuramine + H2O + O2 | - |
Homo sapiens | 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAO-B | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
pIC50 value of rosiridin for MAO B inhibition is 5.38, the pIC50 value for L-deprenyl is 7.23 for MAO B inhibition | Homo sapiens | additional information |