Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.4.3.4 extracted from

  • van Diermen, D.; Marston, A.; Bravo, J.; Reist, M.; Carrupt, P.A.; Hostettmann, K.
    Monoamine oxidase inhibition by Rhodiola rosea L. roots (2009), J. Ethnopharmacol., 122, 397-401.
    View publication on PubMed

Application

Application Comment Organism
medicine Rhodiola rosea roots have potent antidepressant activity by inhibiting MAO A and may also find application in the control of senile dementia by their inhibition of MAO B Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
cinnamyl alcohol compound from Rhodiola rosea extract, inhibits both MAO A and MAO B Homo sapiens
Clorgyline inhibition of MAO A and MAO B Homo sapiens
epigallocatechin gallate dimer compound from Rhodiola rosea extract, inhibits both MAO A and MAO B Homo sapiens
L-deprenyl inhibition of MAO A and MAO B Homo sapiens
additional information Rhodiola rosea roots have potent antidepressant activity by inhibiting MAO A and may also find application in the control of senile dementia by their inhibition of MAO B, no inhibition of both isozymes by rosavin, rosarin, and rosin Homo sapiens
rhodiocyanoside A compound from Rhodiola rosea extract, inhibits MAO B, not MAO A Homo sapiens
rhodioloside B compound from Rhodiola rosea extract, inhibits MAO B, not MAO A Homo sapiens
rosiridin compound from Rhodiola rosea extract, inhibits both MAO A and MAO B Homo sapiens
salidroside compound from Rhodiola rosea extract, inhibits MAO B, not MAO A Homo sapiens
triandrin compound from Rhodiola rosea extract, inhibits MAO B, not MAO A Homo sapiens
tyrosol compound from Rhodiola rosea extract, inhibits MAO B, not MAO A Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P27338
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
kynuramine + H2O + O2
-
Homo sapiens 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
?

Synonyms

Synonyms Comment Organism
MAO-B
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
pIC50 value of rosiridin for MAO B inhibition is 5.38, the pIC50 value for L-deprenyl is 7.23 for MAO B inhibition Homo sapiens additional information