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(E)-geranyl diphosphate + isopentenyl diphosphate
(2Z,6E)-farnesyl diphosphate + diphosphate
(E)-neryl diphosphate + isopentenyl diphosphate
(2Z,6Z)-farnesyl diphosphate + diphosphate
(E,E)-farnesyl diphosphate + isopentenyl diphosphate
? + diphosphate
8-hydroxygeranyl diphosphate + isopentenyl diphosphate
(2Z)-12-hydroxyfarnesyl diphosphate + (2Z, 6Z)-16-hydroxygeranylgeranyl diphosphate + diphosphate
-
16.7% yield of (2Z)-12-hydroxyfarnesyl diphosphate, 6.6% yield of (2Z, 6Z)-16-hydroxygeranylgeranyl diphosphate
-
?
geranyl diphosphate + isopentenyl diphosphate
(2Z,6E)-farnesyl diphosphate + diphosphate
geranyl diphosphate + isopentenyl diphosphate
diphosphate + (2Z,6E)-farnesyl diphosphate
additional information
?
-
(E)-geranyl diphosphate + isopentenyl diphosphate
(2Z,6E)-farnesyl diphosphate + diphosphate
-
stereospecific reaction
-
-
?
(E)-geranyl diphosphate + isopentenyl diphosphate
(2Z,6E)-farnesyl diphosphate + diphosphate
-
stereospecific reaction
-
-
?
(E)-neryl diphosphate + isopentenyl diphosphate
(2Z,6Z)-farnesyl diphosphate + diphosphate
-
stereospecific reaction
-
-
?
(E)-neryl diphosphate + isopentenyl diphosphate
(2Z,6Z)-farnesyl diphosphate + diphosphate
-
stereospecific reaction
-
-
?
(E,E)-farnesyl diphosphate + isopentenyl diphosphate
? + diphosphate
-
no substrate for wild-type enzyme. Mutant L84A/L85A synthesizes prenyl diphosphates containing 50 carbon atoms
-
?
(E,E)-farnesyl diphosphate + isopentenyl diphosphate
? + diphosphate
-
no substrate for wild-type enzyme. Mutant L84A/L85A synthesizes prenyl diphosphates containing 50 carbon atoms
-
?
geranyl diphosphate + isopentenyl diphosphate
(2Z,6E)-farnesyl diphosphate + diphosphate
-
-
-
?
geranyl diphosphate + isopentenyl diphosphate
(2Z,6E)-farnesyl diphosphate + diphosphate
-
product of wild-type.Mutant L84A/L85A synthesizes prenyl diphosphates containing 20 carbon atoms
-
?
geranyl diphosphate + isopentenyl diphosphate
(2Z,6E)-farnesyl diphosphate + diphosphate
-
stereospecific reaction
i.e. omega,E,Z-farnesyl diphosphate
-
?
geranyl diphosphate + isopentenyl diphosphate
(2Z,6E)-farnesyl diphosphate + diphosphate
-
step in polyprenylphosphate biosynthesis, overview
-
-
?
geranyl diphosphate + isopentenyl diphosphate
(2Z,6E)-farnesyl diphosphate + diphosphate
-
stereospecific reaction
i.e. omega,E,Z-farnesyl diphosphate
-
?
geranyl diphosphate + isopentenyl diphosphate
(2Z,6E)-farnesyl diphosphate + diphosphate
-
step in polyprenylphosphate biosynthesis, overview
-
-
?
geranyl diphosphate + isopentenyl diphosphate
(2Z,6E)-farnesyl diphosphate + diphosphate
-
product of wild-type.Mutant L84A/L85A synthesizes prenyl diphosphates containing 20 carbon atoms
-
?
geranyl diphosphate + isopentenyl diphosphate
(2Z,6E)-farnesyl diphosphate + diphosphate
-
-
-
?
geranyl diphosphate + isopentenyl diphosphate
(2Z,6E)-farnesyl diphosphate + diphosphate
-
-
-
-
?
geranyl diphosphate + isopentenyl diphosphate
(2Z,6E)-farnesyl diphosphate + diphosphate
-
-
-
-
?
geranyl diphosphate + isopentenyl diphosphate
(2Z,6E)-farnesyl diphosphate + diphosphate
-
stereospecific reaction
i.e. omega,E,Z-farnesyl diphosphate
-
?
geranyl diphosphate + isopentenyl diphosphate
(2Z,6E)-farnesyl diphosphate + diphosphate
-
step in polyprenylphosphate biosynthesis, overview
-
-
?
geranyl diphosphate + isopentenyl diphosphate
(2Z,6E)-farnesyl diphosphate + diphosphate
-
-
-
-
?
geranyl diphosphate + isopentenyl diphosphate
(2Z,6E)-farnesyl diphosphate + diphosphate
-
-
-
-
?
geranyl diphosphate + isopentenyl diphosphate
diphosphate + (2Z,6E)-farnesyl diphosphate
-
only geranyl diphosphate is the acceptable substrate among the three allylic substrates, dimethylallyl diphosphate, geranyl diphosphate, and farnesyl diphosphate
-
-
?
geranyl diphosphate + isopentenyl diphosphate
diphosphate + (2Z,6E)-farnesyl diphosphate
-
only geranyl diphosphate is the acceptable substrate among the three allylic substrates, dimethylallyl diphosphate, geranyl diphosphate, and farnesyl diphosphate
-
-
?
geranyl diphosphate + isopentenyl diphosphate
diphosphate + (2Z,6E)-farnesyl diphosphate
-
-
-
?
geranyl diphosphate + isopentenyl diphosphate
diphosphate + (2Z,6E)-farnesyl diphosphate
-
-
-
-
?
geranyl diphosphate + isopentenyl diphosphate
diphosphate + (2Z,6E)-farnesyl diphosphate
-
only geranyl diphosphate is the acceptable substrate among the three allylic substrates, dimethylallyl diphosphate, geranyl diphosphate, and farnesyl diphosphate
-
-
?
geranyl diphosphate + isopentenyl diphosphate
diphosphate + (2Z,6E)-farnesyl diphosphate
-
-
-
?
geranyl diphosphate + isopentenyl diphosphate
diphosphate + (2Z,6E)-farnesyl diphosphate
-
only geranyl diphosphate is the acceptable substrate among the three allylic substrates, dimethylallyl diphosphate, geranyl diphosphate, and farnesyl diphosphate
-
-
?
additional information
?
-
the enzyme cannot use dimethylallyl diphosphate as a substrate
-
-
?
additional information
?
-
-
the enzyme cannot use dimethylallyl diphosphate as a substrate
-
-
?
additional information
?
-
the enzyme does not catalyze reactions between 8-tetrahydropyran-2-yloxygeranyl diphosphate and isopentenyl diphosphate
-
-
?
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(E)-geranyl diphosphate + isopentenyl diphosphate
(2Z,6E)-farnesyl diphosphate + diphosphate
geranyl diphosphate + isopentenyl diphosphate
(2Z,6E)-farnesyl diphosphate + diphosphate
geranyl diphosphate + isopentenyl diphosphate
diphosphate + (2Z,6E)-farnesyl diphosphate
-
-
-
?
(E)-geranyl diphosphate + isopentenyl diphosphate
(2Z,6E)-farnesyl diphosphate + diphosphate
-
stereospecific reaction
-
-
?
(E)-geranyl diphosphate + isopentenyl diphosphate
(2Z,6E)-farnesyl diphosphate + diphosphate
-
stereospecific reaction
-
-
?
geranyl diphosphate + isopentenyl diphosphate
(2Z,6E)-farnesyl diphosphate + diphosphate
-
step in polyprenylphosphate biosynthesis, overview
-
-
?
geranyl diphosphate + isopentenyl diphosphate
(2Z,6E)-farnesyl diphosphate + diphosphate
-
step in polyprenylphosphate biosynthesis, overview
-
-
?
geranyl diphosphate + isopentenyl diphosphate
(2Z,6E)-farnesyl diphosphate + diphosphate
-
step in polyprenylphosphate biosynthesis, overview
-
-
?
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Crick, D.C.; Schulbach, M.C.; Zink, E.E.; Macchia, M.; Barontini, S.; Besra, G.S.; Brennan, P.J.
Polyprenyl phosphate biosynthesis in Mycobacterium tuberculosis and Mycobacterium smegmatis
J. Bacteriol.
182
5771-5778
2000
Mycobacterium tuberculosis, Mycolicibacterium smegmatis, Mycobacterium tuberculosis H37Rv
brenda
Schulbach, M.C.; Brennan, P.J.; Crick, D.C.
Identification of a short (C15) chain Z-isoprenyl diphosphate synthase and a homologous long (C50) chain isoprenyl disphosphate synthase in Mycobacterium tuberculosis
J. Biol. Chem.
275
22876-22881
2000
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
brenda
Schulbach, M.C.; Mahapatra, S.; Macchia, M.; Barontini, S.; Papi, C.; Minutolo, F.; Bertini, S.; Brennan, P.J.; Crick, D.C.
Purification, enzymatic characterization, and inhibition of the Z-farnesyl diphosphate synthase from Mycobacterium tuberculosis
J. Biol. Chem.
276
11624-11630
2001
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
brenda
Ambo, T.; Noike, M.; Kurokawa, H.; Koyama, T.
Cloning and functional analysis of novel short-chain cis-prenyltransferases
Biochem. Biophys. Res. Commun.
375
536-540
2008
Corynebacterium glutamicum, Mycobacterium tuberculosis, Thermobifida fusca, Corynebacterium efficiens
brenda
Wang, W.; Dong, C.; McNeil, M.; Kaur, D.; Mahapatra, S.; Crick, D.C.; Naismith, J.H.
The structural basis of chain length control in Rv1086
J. Mol. Biol.
381
129-140
2008
Mycobacterium tuberculosis (P9WFF5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WFF5)
brenda
Sato, T.; Takizawa, K.; Orito, Y.; Kudo, H.; Hoshino, T.
Insight into C35 terpene biosyntheses by nonpathogenic Mycobacterium species: functional analyses of three Z-prenyltransferases and identification of dehydroheptaprenylcyclines
ChemBioChem
11
1874-1881
2010
Mycolicibacterium vanbaalenii, Mycolicibacterium chlorophenolicum, Mycobacterium tuberculosis (P9WFF5), Mycobacterium tuberculosis H37Rv (P9WFF5), Mycolicibacterium vanbaalenii JCM 13017, Mycolicibacterium chlorophenolicum JCM 7439
brenda
Nagaki, M.; Ichijo, T.; Kobashi, R.; Yagihashi, Y.; Musashi, T.; Kawakami, J.; Ohya, N.; Gotoh, T.; Sagami, H.
Substrate specificities of E- and Z-farnesyl diphosphate synthases with substrate analogs
J. Mol. Catal. B
80
1-6
2012
Thermobifida fusca (Q47SS3)
-
brenda
Wang, C.; Zhou, J.; Jang, H.J.; Yoon, S.H.; Kim, J.Y.; Lee, S.G.; Choi, E.S.; Kim, S.W.
Engineered heterologous FPP synthases-mediated Z,E-FPP synthesis in E. coli
Metab. Eng.
18
53-59
2013
Mycobacterium tuberculosis (P9WFF5), Mycobacterium tuberculosis
brenda