Information on EC 2.1.1.226 - 23S rRNA (cytidine1920-2'-O)-methyltransferase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.1.1.226
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RECOMMENDED NAME
GeneOntology No.
23S rRNA (cytidine1920-2'-O)-methyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + cytidine1920 in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
show the reaction diagram
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:23S rRNA (cytidine1920-2'-O)-methyltransferase
The bifunctional enzyme from Mycobacterium tuberculosis 2'-O-methylates cytidine1920 in helix 69 of 23S rRNA and cytidine1409 in helix 44 of 16S rRNA (cf. EC 2.1.1.227, 16S rRNA (cytidine1409-2'-O)-methyltransferase). These methylations result in increased susceptibility to the antibiotics capreomycin and viomycin.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
gene tlyA
UniProt
Manually annotated by BRENDA team
gene tlyA
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Manually annotated by BRENDA team
gene tlyA
UniProt
Manually annotated by BRENDA team
gene tlyA
UniProt
Manually annotated by BRENDA team
no activity in Escherichia coli
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Manually annotated by BRENDA team
gene tlyA
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Manually annotated by BRENDA team
gene tlyA
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Manually annotated by BRENDA team
gene tlyA
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + cytidine1920 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
show the reaction diagram
S-adenosyl-L-methionine + cytidine1920 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 50S rRNA
show the reaction diagram
S-adenosyl-L-methionine + cytidine1920 in 50S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 50S rRNA
show the reaction diagram
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + cytidine1920 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
show the reaction diagram
S-adenosyl-L-methionine + cytidine1920 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 50S rRNA
show the reaction diagram
additional information
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
S-adenosyl-L-methionine
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
PDB
SCOP
CATH
ORGANISM
UNIPROT
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
recombinant C-terminally His-tagged enzyme from Escherichia coli
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression of recombinant tlyA in Escherichia coli markedly increases susceptibility to the drugs capreomycin and viomycin
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gene tlyA, DNA and amino acid sequence determination, analysis and comparison, expression in Escherichia coli strain DH1
gene tlyA, recombinant expression of C-terminally His-tagged enzyme in Escherichia coli
Show AA Sequence (566 entries)
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