Cloned (Comment) | Organism |
---|---|
expression of recombinant tlyA in Escherichia coli markedly increases susceptibility to the drugs capreomycin and viomycin | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + cytidine1920 in 23S rRNA | Mycobacterium tuberculosis | - |
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + cytidine1920 in 23S rRNA | - |
Mycobacterium tuberculosis | S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA | - |
? | |
S-adenosyl-L-methionine + cytidine1920 in 23S rRNA | the bifunctional enzyme modifies nucleotide C1409 in helix 44 of 16S rRNA and nucleotide C1920 in helix 69 of 23S rRNA | Mycobacterium tuberculosis | S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA | the exact position of the methyl group in the wild-type rRNAs is verified by MALDI quadrupole-TOF tandem MS analysis | ? |
Synonyms | Comment | Organism |
---|---|---|
TlyA | - |
Mycobacterium tuberculosis |
General Information | Comment | Organism |
---|---|---|
malfunction | the bifunctional enzyme modifies nucleotide C1409 in helix 44 of 16S rRNA and nucleotide C1920 in helix 69 of 23S rRNA. Loss of these rRNA methylations confers resistance to capreomycin and viomycin | Mycobacterium tuberculosis |