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coenzyme B + 6-mercaptohexanoyl-L-threonine phosphate + methylene blue
? + methylene blue
coenzyme B + coenzyme M + methanophenazine
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine
coenzyme B + coenzyme M + methanophenazine
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-O3-phospho-L-threonine + dihydromethanophenazine
coenzyme B + coenzyme M + methanophenazine
N-[7-[(2-sulfoethyl)dithio]heptanoyl]-O3-phospho-L-threonine + dihydromethanophenazine
coenzyme B + coenzyme M + methylene blue
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced methylene blue
-
-
-
-
?
coenzyme B + coenzyme M + reduced ferredoxin + H+ + coenzyme F420
coenzyme B-coenzyme M disulfide + ferredoxin + H2 + reduced coenzyme F420
-
-
-
-
?
coenzyme B-coenzyme M disulfide + dihydromethanophenazine
coenzyme B + coenzyme M + methanophenazine
coenzyme B-coenzyme M disulfide + reduced benzyl viologen
coenzyme B + coenzyme M + benzyl viologen
coenzyme B-coenzyme M disulfide + reduced ferredoxin
coenzyme B + coenzyme M + ferredoxin
coenzyme B-coenzyme M disulfide + reduced methyl viologen
coenzyme B + coenzyme M + methyl viologen
CoM-S-S-CoB + ?
CoM-SH + CoB-SH + ?
DsrC protein disulfide + dihydromethanophenazine
DsrC protein + methanophenazine
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + coenzyme F420H2
coenzyme B + coenzyme M + coenzyme F420
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydro-2-hydroxyphenazine
coenzyme B + coenzyme M
-
-
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine
coenzyme B + coenzyme M + methanophenazine
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + H2
coenzyme B + coenzyme M
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced 2-bromophenazine
coenzyme B + coenzyme M + 2-bromophenazine
-
-
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced 2-hydroxyphenazine
coenzyme B + coenzyme M + 2-hydroxyphenazine
-
-
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced benzyl viologen
coenzyme B + coenzyme M + benzyl viologen
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced benzylviologen
coenzyme B + coenzyme M + benzylviologen
-
-
-
-
?, r
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced benzylviologen
coenzyme B + coenzyme M + oxidized benzyl viologen
-
reaction intermediate is a [4Fe-4S]3+ cluster that is coordinated by one of the cysteines of nearby active-site disulfide or by the sulfur of coenzyme M
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced cytochrome b
coenzyme B + coenzyme M + oxidized cytochrome b
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced methyl viologen
coenzyme B + coenzyme M + methyl viologen
-
ping-pong mechanism
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced methylene blue
coenzyme B + coenzyme M + methylene blue
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced methylviologen
coenzyme B + coenzyme M + methyl viologen
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced methylviologen
coenzyme B + coenzyme M + methylviologen
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced methylviologen
coenzyme B + coenzyme M + oxidized methylviologen
-
-
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced phenazine-1-carboxylic acid
coenzyme B + coenzyme M + phenazine-1-carboxylic acid
-
-
-
-
?
additional information
?
-
coenzyme B + 6-mercaptohexanoyl-L-threonine phosphate + methylene blue
? + methylene blue
-
-
-
-
ir
coenzyme B + 6-mercaptohexanoyl-L-threonine phosphate + methylene blue
? + methylene blue
-
-
-
-
ir
coenzyme B + coenzyme M + methanophenazine
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine
-
-
-
-
?
coenzyme B + coenzyme M + methanophenazine
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine
-
-
-
-
?
coenzyme B + coenzyme M + methanophenazine
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine
-
-
-
-
?
coenzyme B + coenzyme M + methanophenazine
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine
-
-
-
-
?
coenzyme B + coenzyme M + methanophenazine
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine
-
-
-
-
?
coenzyme B + coenzyme M + methanophenazine
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine
-
-
-
-
?
coenzyme B + coenzyme M + methanophenazine
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-O3-phospho-L-threonine + dihydromethanophenazine
-
-
-
-
?
coenzyme B + coenzyme M + methanophenazine
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-O3-phospho-L-threonine + dihydromethanophenazine
-
-
-
-
?
coenzyme B + coenzyme M + methanophenazine
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-O3-phospho-L-threonine + dihydromethanophenazine
-
-
-
-
?
coenzyme B + coenzyme M + methanophenazine
N-[7-[(2-sulfoethyl)dithio]heptanoyl]-O3-phospho-L-threonine + dihydromethanophenazine
-
-
-
-
?
coenzyme B + coenzyme M + methanophenazine
N-[7-[(2-sulfoethyl)dithio]heptanoyl]-O3-phospho-L-threonine + dihydromethanophenazine
-
-
-
-
?
coenzyme B + coenzyme M + methanophenazine
N-[7-[(2-sulfoethyl)dithio]heptanoyl]-O3-phospho-L-threonine + dihydromethanophenazine
-
-
-
-
?
coenzyme B + coenzyme M + methanophenazine
N-[7-[(2-sulfoethyl)dithio]heptanoyl]-O3-phospho-L-threonine + dihydromethanophenazine
-
-
-
-
?
coenzyme B-coenzyme M disulfide + dihydromethanophenazine
coenzyme B + coenzyme M + methanophenazine
-
-
-
-
?
coenzyme B-coenzyme M disulfide + dihydromethanophenazine
coenzyme B + coenzyme M + methanophenazine
-
-
-
-
?
coenzyme B-coenzyme M disulfide + reduced benzyl viologen
coenzyme B + coenzyme M + benzyl viologen
-
-
-
-
?
coenzyme B-coenzyme M disulfide + reduced benzyl viologen
coenzyme B + coenzyme M + benzyl viologen
-
-
-
-
?
coenzyme B-coenzyme M disulfide + reduced ferredoxin
coenzyme B + coenzyme M + ferredoxin
-
-
-
-
?
coenzyme B-coenzyme M disulfide + reduced ferredoxin
coenzyme B + coenzyme M + ferredoxin
-
-
-
-
?
coenzyme B-coenzyme M disulfide + reduced methyl viologen
coenzyme B + coenzyme M + methyl viologen
-
-
-
-
?
coenzyme B-coenzyme M disulfide + reduced methyl viologen
coenzyme B + coenzyme M + methyl viologen
-
-
-
-
?
CoM-S-S-CoB + ?
CoM-SH + CoB-SH + ?
-
-
-
-
?
CoM-S-S-CoB + ?
CoM-SH + CoB-SH + ?
-
-
-
-
?
CoM-S-S-CoB + ?
CoM-SH + CoB-SH + ?
-
-
-
-
?
DsrC protein disulfide + dihydromethanophenazine
DsrC protein + methanophenazine
-
-
-
-
r
DsrC protein disulfide + dihydromethanophenazine
DsrC protein + methanophenazine
-
-
-
-
r
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + coenzyme F420H2
coenzyme B + coenzyme M + coenzyme F420
-
-
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + coenzyme F420H2
coenzyme B + coenzyme M + coenzyme F420
-
-
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + coenzyme F420H2
coenzyme B + coenzyme M + coenzyme F420
-
-
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + coenzyme F420H2
coenzyme B + coenzyme M + coenzyme F420
-
reaction is coupled with the transfer of protons across the membrane of washed vesicles, which drives ATP formation from ADP
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine
coenzyme B + coenzyme M + methanophenazine
-
-
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine
coenzyme B + coenzyme M + methanophenazine
-
ping-pong mechanism
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + H2
coenzyme B + coenzyme M
-
-
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + H2
coenzyme B + coenzyme M
-
energy-conserving step in methanohenic archaea
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + H2
coenzyme B + coenzyme M
-
-
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + H2
coenzyme B + coenzyme M
-
reaction is coupled with transfer of protons across the cytoplasmic membrane. The electrochemical proton gradient thereby generated drives ATP synthesis from ADP plus phosphate. Two different proton-translocating segments are present in the H2:heterodisulfide oxidoreductase system. The first involves the 2-hydroxyphenazine-dependent hydrogenase, and the second involves the heterodisulfide reductase
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + H2
coenzyme B + coenzyme M
-
reaction is independent of coenzyme F420. Reaction is coupled to proton translocation across the cytoplasmic membrane into the lumen of the everted vesicle. The transmembrane electrochemical gradient thereby generated unduces ATP synthesis from ADP + phosphate
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + H2
coenzyme B + coenzyme M
-
-
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + H2
coenzyme B + coenzyme M
-
energy-conserving step
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + H2
coenzyme B + coenzyme M
-
the D-enantiomer of the heterodisulfide is reduced at approximately 35% of the rate observed for the L-form
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + H2
coenzyme B + coenzyme M
-
the D-enantiomer of the heterodisulfide is reduced at approximately 35% of the rate observed for the L-form
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + H2
coenzyme B + coenzyme M
-
-
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + H2
coenzyme B + coenzyme M
-
energy-conserving step
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + H2
coenzyme B + coenzyme M
-
-
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced benzyl viologen
coenzyme B + coenzyme M + benzyl viologen
-
-
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced benzyl viologen
coenzyme B + coenzyme M + benzyl viologen
-
reaction intermediate is a [4Fe-4S]3+ cluster that is coordinated by one of the cysteines of nearby active-site disulfide or by the sulfur of coenzyme M
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced cytochrome b
coenzyme B + coenzyme M + oxidized cytochrome b
-
-
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced cytochrome b
coenzyme B + coenzyme M + oxidized cytochrome b
-
electron transfer by a CO dehydrogenase in complex with the heterodisulfide oxidoreductase, no H2 uptake in vivo, reaction is part of the overall reduction of acetate to methane and H2O, also providing a proton-translocation redox system to drive ATP formation
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced methylene blue
coenzyme B + coenzyme M + methylene blue
-
-
-
-
r
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced methylene blue
coenzyme B + coenzyme M + methylene blue
-
-
-
-
r
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced methylviologen
coenzyme B + coenzyme M + methyl viologen
-
-
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced methylviologen
coenzyme B + coenzyme M + methyl viologen
-
-
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced methylviologen
coenzyme B + coenzyme M + methylviologen
-
-
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced methylviologen
coenzyme B + coenzyme M + methylviologen
-
-
-
-
?
additional information
?
-
-
Hdr complexes with F420-nonreducing hydrogenase, formate dehydrogenase, and formyl-MFR dehydrogenase, model of complex of proteins that interact with Hdr, overview
-
-
?
additional information
?
-
-
Hdr complexes with F420-nonreducing hydrogenase, formate dehydrogenase, and formyl-MFR dehydrogenase, model of complex of proteins that interact with Hdr, overview
-
-
?
additional information
?
-
-
no activity with the homodisulfides of coenzyme M and coenzyme B
-
-
?
additional information
?
-
-
no activity with the homodisulfides of coenzyme M and coenzyme B
-
-
?
additional information
?
-
-
homodisulfides of coenzyme M and coenzyme B are not reduced
-
-
?
additional information
?
-
-
the enzyme does not catalyze the reduction of N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine with NADH, NADPH or reduced coenzyme F420
-
-
?
additional information
?
-
-
homodisulfides of coenzyme M and coenzyme B are not reduced
-
-
?
additional information
?
-
-
the enzyme does not catalyze the reduction of N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine with NADH, NADPH or reduced coenzyme F420
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
coenzyme B + coenzyme M + methanophenazine
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine
coenzyme B + coenzyme M + methanophenazine
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-O3-phospho-L-threonine + dihydromethanophenazine
coenzyme B + coenzyme M + methanophenazine
N-[7-[(2-sulfoethyl)dithio]heptanoyl]-O3-phospho-L-threonine + dihydromethanophenazine
coenzyme B-coenzyme M disulfide + dihydromethanophenazine
coenzyme B + coenzyme M + methanophenazine
coenzyme B-coenzyme M disulfide + reduced ferredoxin
coenzyme B + coenzyme M + ferredoxin
DsrC protein disulfide + dihydromethanophenazine
DsrC protein + methanophenazine
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + coenzyme F420H2
coenzyme B + coenzyme M + coenzyme F420
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine
coenzyme B + coenzyme M + methanophenazine
-
-
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + H2
coenzyme B + coenzyme M
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced cytochrome b
coenzyme B + coenzyme M + oxidized cytochrome b
-
electron transfer by a CO dehydrogenase in complex with the heterodisulfide oxidoreductase, no H2 uptake in vivo, reaction is part of the overall reduction of acetate to methane and H2O, also providing a proton-translocation redox system to drive ATP formation
-
-
?
additional information
?
-
coenzyme B + coenzyme M + methanophenazine
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine
-
-
-
-
?
coenzyme B + coenzyme M + methanophenazine
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine
-
-
-
-
?
coenzyme B + coenzyme M + methanophenazine
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine
-
-
-
-
?
coenzyme B + coenzyme M + methanophenazine
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine
-
-
-
-
?
coenzyme B + coenzyme M + methanophenazine
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-O3-phospho-L-threonine + dihydromethanophenazine
-
-
-
-
?
coenzyme B + coenzyme M + methanophenazine
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-O3-phospho-L-threonine + dihydromethanophenazine
-
-
-
-
?
coenzyme B + coenzyme M + methanophenazine
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-O3-phospho-L-threonine + dihydromethanophenazine
-
-
-
-
?
coenzyme B + coenzyme M + methanophenazine
N-[7-[(2-sulfoethyl)dithio]heptanoyl]-O3-phospho-L-threonine + dihydromethanophenazine
-
-
-
-
?
coenzyme B + coenzyme M + methanophenazine
N-[7-[(2-sulfoethyl)dithio]heptanoyl]-O3-phospho-L-threonine + dihydromethanophenazine
-
-
-
-
?
coenzyme B + coenzyme M + methanophenazine
N-[7-[(2-sulfoethyl)dithio]heptanoyl]-O3-phospho-L-threonine + dihydromethanophenazine
-
-
-
-
?
coenzyme B + coenzyme M + methanophenazine
N-[7-[(2-sulfoethyl)dithio]heptanoyl]-O3-phospho-L-threonine + dihydromethanophenazine
-
-
-
-
?
coenzyme B-coenzyme M disulfide + dihydromethanophenazine
coenzyme B + coenzyme M + methanophenazine
-
-
-
-
?
coenzyme B-coenzyme M disulfide + dihydromethanophenazine
coenzyme B + coenzyme M + methanophenazine
-
-
-
-
?
coenzyme B-coenzyme M disulfide + reduced ferredoxin
coenzyme B + coenzyme M + ferredoxin
-
-
-
-
?
coenzyme B-coenzyme M disulfide + reduced ferredoxin
coenzyme B + coenzyme M + ferredoxin
-
-
-
-
?
DsrC protein disulfide + dihydromethanophenazine
DsrC protein + methanophenazine
-
-
-
-
r
DsrC protein disulfide + dihydromethanophenazine
DsrC protein + methanophenazine
-
-
-
-
r
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + coenzyme F420H2
coenzyme B + coenzyme M + coenzyme F420
-
-
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + coenzyme F420H2
coenzyme B + coenzyme M + coenzyme F420
-
reaction is coupled with the transfer of protons across the membrane of washed vesicles, which drives ATP formation from ADP
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + H2
coenzyme B + coenzyme M
-
-
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + H2
coenzyme B + coenzyme M
-
energy-conserving step in methanohenic archaea
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + H2
coenzyme B + coenzyme M
-
reaction is coupled with transfer of protons across the cytoplasmic membrane. The electrochemical proton gradient thereby generated drives ATP synthesis from ADP plus phosphate. Two different proton-translocating segments are present in the H2:heterodisulfide oxidoreductase system. The first involves the 2-hydroxyphenazine-dependent hydrogenase, and the second involves the heterodisulfide reductase
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + H2
coenzyme B + coenzyme M
-
energy-conserving step
-
-
?
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + H2
coenzyme B + coenzyme M
-
energy-conserving step
-
-
?
additional information
?
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Hdr complexes with F420-nonreducing hydrogenase, formate dehydrogenase, and formyl-MFR dehydrogenase, model of complex of proteins that interact with Hdr, overview
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Hdr complexes with F420-nonreducing hydrogenase, formate dehydrogenase, and formyl-MFR dehydrogenase, model of complex of proteins that interact with Hdr, overview
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Methanococcus maripaludis, Methanococcus maripaludis MM1265
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