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Literature summary for 1.8.98.1 extracted from
- Heterodisulfide reductase from methanogenic archaea: a new catalytic role for an iron-sulfur cluster (2005), Biol. Chem., 386, 961-970.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | HDR is not inhibited by cysteine alkylating reagents at concentrations up to 2 mM | Methanosarcina barkeri | |
| additional information | HDR is not inhibited by cysteine alkylating reagents at concentrations up to 2 mM | Methanosarcina thermophila | |
| additional information | HDR is not inhibited by cysteine alkylating reagents at concentrations up to 2 mM | Methanothermobacter marburgensis |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Iron | coenzyme M binds to a [4Fe-4S] cluster in the active site | Methanosarcina barkeri |  |
| Iron | coenzyme M binds to a [4Fe-4S] cluster in the active site | Methanosarcina thermophila | |
| Iron | coenzyme M binds to a [4Fe-4S] cluster in the active site | Methanothermobacter marburgensis | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Methanosarcina barkeri | - |
- |
- |
| Methanosarcina thermophila | - |
- |
- |
| Methanothermobacter marburgensis | - |
formerly Methanobacterium thermoautotrophicum strain Marburg | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Methanosarcina barkeri |
- |
Methanosarcina thermophila |
- |
Methanothermobacter marburgensis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| coenzyme B + coenzyme M + methanophenazine | - |
Methanosarcina barkeri | N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine | - |
? | |
| coenzyme B + coenzyme M + methanophenazine | - |
Methanosarcina thermophila | N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine | - |
? | |
| coenzyme B + coenzyme M + methanophenazine | - |
Methanothermobacter marburgensis | N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine | - |
? | |
| CoM-S-S-CoB + ? | - |
Methanosarcina barkeri | CoM-SH + CoB-SH + ? | - |
? | |
| CoM-S-S-CoB + ? | - |
Methanosarcina thermophila | CoM-SH + CoB-SH + ? | - |
? | |
| CoM-S-S-CoB + ? | - |
Methanothermobacter marburgensis | CoM-SH + CoB-SH + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HDR | - |
Methanosarcina barkeri |
| HDR | - |
Methanosarcina thermophila |
| HDR | - |
Methanothermobacter marburgensis |
| HdrB | catalytic subunit of HDR | Methanothermobacter marburgensis |
| HdrC | catalytic subunit of HDR | Methanothermobacter marburgensis |
| HdrD | catalytic subunit of HDR | Methanosarcina barkeri |
| heterodisulfide reductase | - |
Methanosarcina barkeri |
| heterodisulfide reductase | - |
Methanosarcina thermophila |
| heterodisulfide reductase | - |
Methanothermobacter marburgensis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Methanosarcina barkeri | |
| FAD | - |
Methanosarcina thermophila | |
| FAD | - |
Methanothermobacter marburgensis | |
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