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2.7.2.2: carbamate kinase

This is an abbreviated version!
For detailed information about carbamate kinase, go to the full flat file.

Word Map on EC 2.7.2.2

Reaction

ATP
+
Carbamate
=
ADP
 +
Carbamoyl phosphate

Synonyms

ACK, anabolic carbamyl kinase, ArcC, carbamate kinase, carbamoyl phosphokinase, carbamyl phosphokinase, catabolic carbamyl kinase, Cbk, CCK, CK, CK-like CPS, CKase, GlcK, kinase, carbamate (phosphorylating), putrescine synthase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.2 Phosphotransferases with a carboxy group as acceptor
                2.7.2.2 carbamate kinase

Inhibitors

Inhibitors on EC 2.7.2.2 - carbamate kinase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1R,2S,5S)-2-isopropyl-5-methylcyclohexanol
-
-
2,3-Butanedione
-
in borate buffer, inactivation, implying the presence of an essential arginine
adenosine(5')hexaphospho(5')adenosine
-
adenosine(5')pentaphospho(5')adenosine
-
bicarbonate
-
slight substrate inhibition
Disulfiram
the anti-alcoholism drug kills the trophozoites and inhibits the enzyme. Disulfiram acts by modifying Cys-242 adjacent to the active site and cures giardiasis in mice. The compound thiocarbamoylates Cys242, a residue located at the edge of the active site. The modified Cys242 prevents a conformational transition of a loop adjacent to the ADP/ATP binding site, which is required for the stacking of Tyr245 side chain against the adenine moiety
heptadecanoic acid
-
iodoacetamide
-
weak
L-arginine
slight inhibition
methyl (11Z)-11-icosen-14-ynoate
-
-
metronidazole
irreversible inactivation mechanism, the thiuram compounds can circumvent the resistance mechanism that renders metronidazole ineffectiveness in drug resistance cases of giardiasis
MgADP-
-
competitive to ATP
neophytadiene
-
-
p-hydroxymercuribenzoate
-
-
Phosphonoacetate
competitive to carbamoyl phosphate
Silver-Tris
-
-
-
additional information
-