2.7.2.2: carbamate kinase
This is an abbreviated version!
For detailed information about carbamate kinase, go to the full flat file.
Word Map on EC 2.7.2.2
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2.7.2.2
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ornithine
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deiminase
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dihydrolase
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citrulline
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transcarbamoylase
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carbamyltransferase
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arcabc
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n-acetyl-l-glutamate
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drug development
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degradation
- 2.7.2.2
- ornithine
- deiminase
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dihydrolase
- citrulline
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transcarbamoylase
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carbamyltransferase
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arcabc
- n-acetyl-l-glutamate
- drug development
- degradation
Reaction
Synonyms
ACK, anabolic carbamyl kinase, ArcC, carbamate kinase, carbamoyl phosphokinase, carbamyl phosphokinase, catabolic carbamyl kinase, Cbk, CCK, CK, CK-like CPS, CKase, GlcK, kinase, carbamate (phosphorylating), putrescine synthase
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Application on EC 2.7.2.2 - carbamate kinase
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degradation
drug development
additional information
degradation
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arginine is metabolized by the arginine deiminase pathway
because the L-arginine pathway is essential for Giardia lamblia survival and absent in high eukaryotes including humans, the enzyme is a potential target for drug development
drug development
the enzyme is a good drug target and disulfiram may be repurposed as antigiardiasis drug
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putative gene for carbamate kinase is ef0735 on the DNA strand of the Enterococcus faecalis V583 chromosome. The arginine deiminase pathway of arginine catabolism probably supplies the genes for PTC and CK but not those for the agmatine/putrescine antiporter
additional information
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putative gene for carbamate kinase is ef0735 on the DNA strand of the Enterococcus faecalis V583 chromosome. The arginine deiminase pathway of arginine catabolism probably supplies the genes for PTC and CK but not those for the agmatine/putrescine antiporter
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