2.7.1.183: glycoprotein-mannosyl O6-kinase
This is an abbreviated version!
For detailed information about glycoprotein-mannosyl O6-kinase, go to the full flat file.
Word Map on EC 2.7.1.183
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2.7.1.183
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muscular
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dystrophy
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glycan
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dystroglycan
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o-mannosylated
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laminin
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dystroglycanopathies
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matriglycan
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basement
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creatine
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laminin-binding
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alpha-dystroglycan
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walker-warburg
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trisaccharide
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limb-girdle
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alpha-dystroglycanopathy
- 2.7.1.183
-
muscular
- dystrophy
-
glycan
-
dystroglycan
-
o-mannosylated
- laminin
-
dystroglycanopathies
-
matriglycan
-
basement
- creatine
-
laminin-binding
- alpha-dystroglycan
-
walker-warburg
-
trisaccharide
-
limb-girdle
-
alpha-dystroglycanopathy
Reaction
Synonyms
DrPOMK, HsPOMK, O-mannose kinase, POMK, protein kinase-like protein SgK196, protein O-mannose kinase, protein O-mannosyl kinase, protein-O-mannose kinase, SGK196, sugen kinase 196
ECTree
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Subunits
Subunits on EC 2.7.1.183 - glycoprotein-mannosyl O6-kinase
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additional information
as a type II transmembrane protein, SGK196 consists of a cytoplasmic tail, one transmembrane helix, and a luminal domain. Lack of functional motifs of protein kinases including Asp-Phe-Gly (DFG), His-Arg-Asp (HRD) and conserved Lys residues in the primary structure of SGK196
additional information
Homo sapiens POMK (HsPOMK) contains a type II transmembrane (TM) domain and a lumenal kinase domain
additional information
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Homo sapiens POMK (HsPOMK) contains a type II transmembrane (TM) domain and a lumenal kinase domain
additional information
the POMK catalytic domain takes a typical protein kinase fold consisting of N- and C-lobes. The N-lobe goes from C54 to P152 and comprises five beta-strands arranged in an antiparallel beta-sheet with two alpha-helices (alpha1-2), whereas C-lobe is from L153 to L337 and is composed of nine alpha-helices (alpha3-11) with a beta-hairpin (beta6-7)