2.7.1.183: glycoprotein-mannosyl O6-kinase

This is an abbreviated version!
For detailed information about glycoprotein-mannosyl O6-kinase, go to the full flat file.

Word Map on EC 2.7.1.183

2.7.1.183

muscular

dystrophy

glycan

dystroglycan

o-mannosylated

laminin

dystroglycanopathies

matriglycan

basement

creatine

laminin-binding

alpha-dystroglycan

walker-warburg

trisaccharide

limb-girdle

alpha-dystroglycanopathy

Reaction

O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl/L-seryl-[protein]

O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-(6-phospho)mannosyl]-L-threonyl/L-seryl-[protein]

Synonyms

DrPOMK, HsPOMK, O-mannose kinase, POMK, protein kinase-like protein SgK196, protein O-mannose kinase, protein O-mannosyl kinase, protein-O-mannose kinase, SGK196, sugen kinase 196

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.1.183 glycoprotein-mannosyl O6-kinase

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Results	in table
725	AA Sequence
4	Cloned(Commentary)
5	Cofactor
2	Crystallization (Commentary)
14	Disease/ Diagnostics
17	General Information
1	KM Value [mM]
2	Localization
6	Metals/Ions
10	Natural Substrates/ Products (Substrates)
6	Organism
3	Pathway
1	PDB ID
4	Posttranslational Modification
21	Protein Variants
1	Reaction
6	Reference
11	Source Tissue
13	Substrates and Products (Substrate)
4	Subunits
27	Synonyms
1	Systematic Name

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Reference on EC 2.7.1.183 - glycoprotein-mannosyl O6-kinase

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726488

Yoshida-Moriguchi, T.; Willer, T.; Anderson, M.E.; Venzke, D.; Whyte, T.; Muntoni, F.; Lee, H.; Nelson, S.F.; Yu, L.; Campbell, K.P.

SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function

Science

341

896-899

2013

Homo sapiens

23929950

760981

Zhu, Q.; Venzke, D.; Walimbe, A.S.; Anderson, M.E.; Fu, Q.; Kinch, L.N.; Wang, W.; Chen, X.; Grishin, N.V.; Huang, N.; Yu, L.; Dixon, J.E.; Campbell, K.P.; Xiao, J.

Structure of protein O-mannose kinase reveals a unique active site architecture

eLife

e22238

2016

Danio rerio (Q5U3W1), Danio rerio, Homo sapiens (Q9H5K3), Homo sapiens

27879205

761207

Nagae, M.; Mishra, S.K.; Neyazaki, M.; Oi, R.; Ikeda, A.; Matsugaki, N.; Akashi, S.; Manya, H.; Mizuno, M.; Yagi, H.; Kato, K.; Senda, T.; Endo, T.; Nogi, T.; Yamaguchi, Y.

3D structural analysis of protein O-mannosyl kinase, POMK, a causative gene product of dystroglycanopathy

Genes Cells

348-359

2017

Mus musculus (Q3TUA9)

28251761

762066

Xu, C.; Zhang, M.; Bian, L.; Li, Y.; Yao, Y.; Li, D.

N-glycosylated SGK196 suppresses the metastasis of basal-like breast cancer cells

Oncogenesis

2020

Homo sapiens (Q9H5K3)

31913260

762091

Paul, L.; Rupprich, K.; Della Marina, A.; Stein, A.; Elgizouli, M.; Kaiser, F.J.; Schweiger, B.; Koeninger, A.; Iannaccone, A.; Hehr, U.; Koelbel, H.; Roos, A.; Schara-Schmidt, U.; Kuechler, A.

Further evidence for POMK as candidate gene for WWS with meningoencephalocele

Orphanet J. Rare Dis.

242

2020

Homo sapiens (Q9H5K3)

32907597