2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase

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For detailed information about phosphatidylinositol-4,5-bisphosphate 3-kinase, go to the full flat file.

Reaction

Synonyms

class I phosphoinositide 3-kinase, class I PI3K, class IA phosphatidylinositol 3-kinase, class IA phosphatidylinositol-4,5-bisphosphate 3-kinase, CXCR2/phosphatidylinositol 3-kinase gamma, kinase (phosphorylating), phosphatidylinositol 4,5-diphosphate 3-, More, p101-PI3K, p110alpha, p110beta, p110delta, p110delta PI 3-kinase, p110gamma/p101, P120-PI3K, phosphatidyl-inositol-3-kinase, phosphatidylinositol (4,5)-bisphosphate 3-hydroxykinase, phosphatidylinositol 3'-kinase, phosphatidylinositol 3-hydroxyl kinase, phosphatidylinositol 3-kinase alpha, phosphatidylinositol 3-kinase gamma, phosphatidylinositol-4,5-bisphosphate 3-kinase, phosphoinositide 3-kinase, phosphoinositide 3-kinase p110delta, phosphoinositol 3-kinase, PI 3-K, PI 3-kinase, PI-3K, PI3-K, PI3-kinase, PI3K, PI3K p110delta, PI3Kalpha, PI3Kbeta, PI3Kdelta, PI3Kgamma, PI3Kp110delta, PIK3, PIK3CA, Pik3r1, PtdIns(4,5)P2 3-OH kinase, PtdIns-3-kinase p101, PtdIns-3-kinase p110, PtdInsP 3-OH-kinase, type I phosphoinositide 3-kinase

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.153 phosphatidylinositol-4,5-bisphosphate 3-kinase

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Results	in table
41	Activating Compound
3848	AA Sequence
10	Application
2	CAS Registry Number
22	Cloned(Commentary)
39	Cofactor
5	Crystallization (Commentary)
23028	Disease/ Diagnostics
4	Expression
85	General Information
57	IC50 Value
125	Inhibitors
1	KM Value [mM]
18	Localization
21	Metals/Ions
12	Molecular Weight [Da]
74	Natural Substrates/ Products (Substrates)
396	Organism
3	Pathway
265	PDB ID
10	pH Optimum
1	Posttranslational Modification
65	Protein Variants
5	Purification (Commentary)
1	Reaction
1	Reaction Type
117	Reference
146	Source Tissue
121	Substrates and Products (Substrate)
45	Subunits
133	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]

Expression

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Expression on EC 2.7.1.153 - phosphatidylinositol-4,5-bisphosphate 3-kinase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

gain of copy number of PIK3CA gene by gene amplification in mantle cell lymphoma is one mechanism of oncogenic activation of PI3K. Expression of PIK3CA in mantle cell lymphoma correlates with gene copy numbers determined by real-time PCR, overview

Homo sapiens

-

708158

upregulation of class I PI3K isozymes in cancer cells

2 entries

virulent Legionella pneumophila infection induces PI3K in human macrophages, while PI3K and protein kinase B, PKB/Akt, activities are lower in macrophages infected with an avirulent bacterial strain

Homo sapiens

-

710351

upregulation of class I PI3K isozymes in cancer cells

Mus musculus

-

710598

upregulation of class I PI3K isozymes in cancer cells

Homo sapiens

-

710598