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Literature summary for 2.7.1.153 extracted from

  • Tachado, S.D.; Samrakandi, M.M.; Cirillo, J.D.
    Non-opsonic phagocytosis of Legionella pneumophila by macrophages is mediated by phosphatidylinositol 3-kinase (2008), PLoS ONE, 3, e3324.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information virulent Legionella pneumophila infection activates PI3K 10fold in vivo, the avirulent bacteria strain Lp-14 activates 4fold in vivo Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of the dominant negative PI3K mutant in J774A.1 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information construction of a dominant negative PI3K mutant by PCR cloning. Legionella pneumophila entry into macrophages expressing the mutant is reduced Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
LY294002
-
Homo sapiens
Wortmannin
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Homo sapiens
-
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
?

Subunits

Subunits Comment Organism
More p85alpha subunit of class I PI3K Homo sapiens

Synonyms

Synonyms Comment Organism
PI3K
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
assay at room temperature Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000025
-
inhibition of bacterial entry into macrophages Homo sapiens Wortmannin
0.008
-
inhibition of bacterial entry into macrophages Homo sapiens LY294002

Expression

Organism Comment Expression
Homo sapiens virulent Legionella pneumophila infection induces PI3K in human macrophages, while PI3K and protein kinase B, PKB/Akt, activities are lower in macrophages infected with an avirulent bacterial strain up

General Information

General Information Comment Organism
physiological function phosphatidylinositol 3-kinase mediates non-opsonic phagocytosis of Legionella pneumophila by macrophages Homo sapiens