2.7.1.108: dolichol kinase

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For detailed information about dolichol kinase, go to the full flat file.

Reaction

Synonyms

At3g45040, AtDOK1, cytidine-5-triphosphate (CTP) dependent dolichol kinase, DK, DK1, DOK1, dolichol kinase, dolichol kinase 1, dolichol phosphokinase, dolichol-specific kinase, DOLK, SEC59, Sec59p

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.108 dolichol kinase

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Results	in table
17	Activating Compound
2592	AA Sequence
1	CAS Registry Number
7	Cloned(Commentary)
7	Cofactor
32	Disease/ Diagnostics
18	General Information
24	Inhibitors
1	Ki Value [mM]
18	KM Value [mM]
38	Localization
40	Metals/Ions
2	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
693	Organism
5	Pathway
12	pH Optimum
4	pH Range
34	Protein Variants
2	Purification (Commentary)
1	Reaction
6	Reaction Type
37	Reference
40	Source Tissue
5	Specific Activity [micromol/min/mg]
5	Storage Stability
48	Substrates and Products (Substrate)
24	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

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Cloned on EC 2.7.1.108 - dolichol kinase

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

-

Saccharomyces cerevisiae

P20048

640401

gene At3g45040 or AtDOK1, DNA and amino acid sequence determination and analysis, a cytidylyltransferase motif-containing gene, phylogenetic tree. The gene complements defects in the growth and N-linked glycosylation of the Saccharomyces cerevisiae sec59 mutant, deficient in dolichol kinase Sec59p

Arabidopsis thaliana

F4J4C8

739314

gene dolk, genotyping and identification of DOLK mutations

Homo sapiens

Q9UPQ8

739079

gene SEC59, Agrobacterium tumefaciens strain GV3101 is used to transform dok1-1 heterozygous plants with the Venus-tagged wild-type and mutant enzymes (DOK1-Venus fusion proteins), functional complementation of the Saccharomyces cerevisiae sec59 mutant, showing the temperature-sensitive growth phenotype, by expression of the His6-tagged Arabidopsis thaliana enzyme, the sec59 mutant expressing AtDOK1 (G741D) mutant fails to do so, quantitative RT-PCR expression analysis

Arabidopsis thaliana

F4J4C8

761619

gene SEC59, genotyping, DNA and amino acid sequence determination and analysis

Kluyveromyces lactis

Q6CR79

761104

human cDNA complements defect in dolichol kinase activity in Saccharomyces cerevisiae sec59-1 mutant, human SEC59 gene also expressed in Sf-9 cells

Homo sapiens

-

640401

overexpression of normal or variant forms of hDK in CHO cells and in yeast sec59-1 cells

Homo sapiens

-

674673