2.6.99.2: pyridoxine 5'-phosphate synthase

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For detailed information about pyridoxine 5'-phosphate synthase, go to the full flat file.

Reaction

Synonyms

PdxJ, PNP synthase, pyridoxine 5'-phosphate synthesizing enzyme

ECTree

     2 Transferases

         2.6 Transferring nitrogenous groups

             2.6.99 Transferring other nitrogenous groups

                2.6.99.2 pyridoxine 5'-phosphate synthase

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Results	in table
21707	AA Sequence
7	Application
1	CAS Registry Number
4	Crystallization (Commentary)
1	KM Value [mM]
13	Natural Substrates/ Products (Substrates)
15	Organism
5	Pathway
28	PDB ID
2	pH Optimum
2	Protein Variants
1	Purification (Commentary)
7	Reaction
15	Reference
28	Substrates and Products (Substrate)
3	Subunits
19	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 2.6.99.2 - pyridoxine 5'-phosphate synthase

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SYSTEMATIC NAME

IUBMB Comments

1-deoxy-D-xylulose-5-phosphate:3-amino-2-oxopropyl phosphate 3-amino-2-oxopropyltransferase (phosphate-hydrolysing; cyclizing)

In Escherichia coli, the coenzyme pyridoxal 5'-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72 (erythrose-4-phosphate dehydrogenase), EC 1.1.1.290 (4-phosphoerythronate dehydrogenase), EC 2.6.1.52 (phosphoserine transaminase), EC 1.1.1.262 (4-hydroxythreonine-4-phosphate dehydrogenase), EC 2.6.99.2 (pyridoxine 5'-phosphate synthase) and EC 1.4.3.5 (with pyridoxine 5'-phosphate as substrate). 1-Deoxy-D-xylulose cannot replace 1-deoxy-D-xylulose 5-phosphate as a substrate [3].