2.6.99.2: pyridoxine 5'-phosphate synthase
This is an abbreviated version!
For detailed information about pyridoxine 5'-phosphate synthase, go to the full flat file.
Word Map on EC 2.6.99.2
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2.6.99.2
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pharmacology
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pyridoxal
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schiff-base
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symmetry
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closure
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vitamer
- 2.6.99.2
- pharmacology
- pyridoxal
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schiff-base
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symmetry
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closure
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vitamer
Reaction
Synonyms
PdxJ, PNP synthase, pyridoxine 5'-phosphate synthesizing enzyme
ECTree
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Engineering
Engineering on EC 2.6.99.2 - pyridoxine 5'-phosphate synthase
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synthesis
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engineering of a Bacillus subtilis strain that forms significant amounts of pyridoxine via a non-native deoxyxylulose 5'-phosphate-(DXP)-dependent vitamin B6 pathway. The pathway consists of the 4-hydroxy-L-threonine-phosphate dehydrogenase PdxA, the pyridoxine 5'-phosphate synthase PdxJ and the native DXP synthase, Dxs. Bacteria are adapted to tolerate the antimetabolite 4-HO-Thro in order to allow feeding of high amounts of 4-hydroxy-threonine (4-HO-Thr) that can be converted to pyridoxine. The adapted bacteria produce 2834 mg/l pyridoxine from 4-HO-Thr while the wild-type parent produced 12 mg/l pyridoxine. Identification of a better combination of pdxA and pdxJ alleles results in production of 65 mg/l pyridoxine
synthesis
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engineering of a Bacillus subtilis strain that forms significant amounts of pyridoxine via a non-native deoxyxylulose 5'-phosphate-(DXP)-dependent vitamin B6 pathway. The pathway consists of the 4-hydroxy-L-threonine-phosphate dehydrogenase PdxA, the pyridoxine 5'-phosphate synthase PdxJ and the native DXP synthase, Dxs. Bacteria are adapted to tolerate the antimetabolite 4-HO-Thro in order to allow feeding of high amounts of 4-hydroxy-threonine (4-HO-Thr) that can be converted to pyridoxine. The adapted bacteria produce 2834 mg/l pyridoxine from 4-HO-Thr while the wild-type parent produced 12 mg/l pyridoxine. Identification of a better combination of pdxA and pdxJ alleles results in production of 65 mg/l pyridoxine
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