2.6.1.93: neamine transaminase

This is an abbreviated version!
For detailed information about neamine transaminase, go to the full flat file.

Reaction

Synonyms

6'-oxoglucosaminyl:L-glutamate aminotransferase, 6'-oxoparomamine aminotransferase, btrB, glutamate-6'-dehydroparomamine aminotransferase, kacL, Neo-18, neoB, neoN

ECTree

     2 Transferases

         2.6 Transferring nitrogenous groups

             2.6.1 Transaminases

                2.6.1.93 neamine transaminase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
6	AA Sequence
4	Cloned(Commentary)
4	General Information
4	Molecular Weight [Da]
7	Organism
6	Pathway
16	PDB ID
2	Purification (Commentary)
1	Reaction
6	Reference
6	Substrates and Products (Substrate)
15	Synonyms
1	Systematic Name

Systematic Name

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Systematic Name on EC 2.6.1.93 - neamine transaminase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide Go to Systematic Name Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

SYSTEMATIC NAME

IUBMB Comments

neamine:2-oxoglutarate aminotransferase

The reaction occurs in vivo in the opposite direction. Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin B, butirosin, neomycin and ribostamycin. Works in combination with EC 1.1.3.43, paromamine 6-oxidase, to replace the 6'-hydroxy group of paromamine with an amino group. The enzyme from the bacterium Streptomyces kanamyceticus can also catalyse EC 2.6.1.94, 2'-deamino-2'-hydroxyneamine transaminase, which leads to production of kanamycin A [3]. The enzyme from the bacterium Streptomyces fradiae can also catalyse EC 2.6.1.95, leading to production of neomycin C [2].