2.6.1.62: adenosylmethionine-8-amino-7-oxononanoate transaminase
This is an abbreviated version!
For detailed information about adenosylmethionine-8-amino-7-oxononanoate transaminase, go to the full flat file.
Word Map on EC 2.6.1.62
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2.6.1.62
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biotin
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tuberculosis
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dapas
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analysis
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quinonoid
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dethiobiotin
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antepenultimate
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pyridoxal
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auxotrophic
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transamination
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5'-phosphate-dependent
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half-reaction
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bicistronic
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s-adenosylmethionine
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plp-dependent
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biotinylated
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pimeloyl-coa
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alpha-amino
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biotechnology
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pharmacology
- 2.6.1.62
- biotin
- tuberculosis
-
dapas
- analysis
-
quinonoid
- dethiobiotin
-
antepenultimate
- pyridoxal
-
auxotrophic
-
transamination
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5'-phosphate-dependent
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half-reaction
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bicistronic
- s-adenosylmethionine
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plp-dependent
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biotinylated
- pimeloyl-coa
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alpha-amino
- biotechnology
- pharmacology
Reaction
Synonyms
7,8-diaminononanoate transaminase, 7,8-diaminopelargonate synthase, 7,8-diaminopelargonic acid aminotransferase, 7,8-diaminopelargonic acid synthase, 7,8-diaminopelargonic acid transaminase, 7,8-diaminoperlargonic acid aminotransferase, 7-keto-8-aminopelargonic acid aminotransferase, 7-keto-8-aminopelargonic acid-7,8-diaminopelargonic acid aminotransferase, Bio3-Bio1, bioA, DAPA amino transferase, DAPA aminotransferase, DAPA AT, DAPA synthase, DAPA transaminase, diaminopelargonate synthase, diaminopelargonic acid transaminase, diaminoperlargonic acid aminotransferase, More, NCgl2515, Pcryo_0361, S-adenosyl-L-methionine:8-amino-7-oxononanoate aminotransferase, synthase, diaminopelargonate
ECTree
2.6.1.62 adenosylmethionine-8-amino-7-oxononanoate transaminaseAdvanced search results
results (
results (Engineering
Engineering on EC 2.6.1.62 - adenosylmethionine-8-amino-7-oxononanoate transaminase
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
F326Y
I793W
S360Y
D147N
site-directed mutagenesis, mutation of an active site residue, inactive mutant
R253A
site-directed mutagenesis, altered kinetics, highly increased Km for S-adenosyl-L-methionine compared to the wild-type enzyme
R253K
site-directed mutagenesis, altered kinetics compared to the wild-type enzyme
R253M
site-directed mutagenesis, altered kinetics compared to the wild-type enzyme
R253Q
site-directed mutagenesis, altered kinetics compared to the wild-type enzyme
R391A
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increased Km for 7,8-diaminopelargonic acid, no significantly altered crystal structure
Y144F
site-directed mutagenesis, mutation of an active site residue, highly increased Km for S-adenosyl-L-methionine, highly reduced activity compared to the wild-type enzyme
Y17F
site-directed mutagenesis, mutation of an active site residue, highly reduced activity compared to the wild-type enzyme
additional information
F326Y
mutant improves the recombinant enzyme solubility and stability
I793W
mutation predicted to obstruct the observed external crevice. In contrast with the wild-type enzyme, mutant exhibits progress curves with an obvious lag phase with extrapolated transient times of 12 min, as expected for nonchanneling controls
I793W
mutant is predicted to obstruct the observed external crevice. Mutant exhibits progress curves with obvious lag phases with extrapolated transient times of 10 to 12 min, as expected for nonchanneling controls
S360Y
mutation predicted to obstruct the observed external crevice. In contrast with the wild-type enzyme, mutant exhibits progress curves with an obvious lag phase with extrapolated transient times of 10 min, as expected for nonchanneling controls
S360Y
mutant is predicted to obstruct the observed external crevice. Mutant exhibits progress curves with obvious lag phases with extrapolated transient times of 10 to 12 min, as expected for nonchanneling controls
additional information
construction of the gabT NCgl2515-deleted GAD strain SYN203, deletion of the gabT gene encoding GABA-T, and deletion of the additional transaminase gene, NCgl2515, in a gabT-deleted GAD strain
additional information
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construction of the gabT NCgl2515-deleted GAD strain SYN203, deletion of the gabT gene encoding GABA-T, and deletion of the additional transaminase gene, NCgl2515, in a gabT-deleted GAD strain
-
additional information
-
construction of the gabT NCgl2515-deleted GAD strain SYN203, deletion of the gabT gene encoding GABA-T, and deletion of the additional transaminase gene, NCgl2515, in a gabT-deleted GAD strain
-
additional information
-
construction of the gabT NCgl2515-deleted GAD strain SYN203, deletion of the gabT gene encoding GABA-T, and deletion of the additional transaminase gene, NCgl2515, in a gabT-deleted GAD strain
-
additional information
-
construction of the gabT NCgl2515-deleted GAD strain SYN203, deletion of the gabT gene encoding GABA-T, and deletion of the additional transaminase gene, NCgl2515, in a gabT-deleted GAD strain
-
additional information
-
construction of the gabT NCgl2515-deleted GAD strain SYN203, deletion of the gabT gene encoding GABA-T, and deletion of the additional transaminase gene, NCgl2515, in a gabT-deleted GAD strain
-
additional information
-
construction of the gabT NCgl2515-deleted GAD strain SYN203, deletion of the gabT gene encoding GABA-T, and deletion of the additional transaminase gene, NCgl2515, in a gabT-deleted GAD strain
-
