2.5.1.92: (2Z,6Z)-farnesyl diphosphate synthase

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For detailed information about (2Z,6Z)-farnesyl diphosphate synthase, go to the full flat file.

Reaction

Synonyms

cis,cis-farnesyl diphosphate synthase, cis-prenyltransferase, CPT1, FPPase, IDS3, More, short-chain cis-prenyldiphosphate synthase, short-chain SlCPT, SlCPT6, trans-isoprenyl diphosphate synthase, Z,Z-farnesyl diphosphate synthase, Z,Z-farnesyl pyrophosphate synthase, Z,Z-FPP synthase, zFPS

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.92 (2Z,6Z)-farnesyl diphosphate synthase

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Results	in table
3	AA Sequence
2	Application
5	Cloned(Commentary)
2	Crystallization (Commentary)
7	General Information
2	Inhibitors
7	kcat/KM [mM/s]
1	Ki Value [mM]
13	KM Value [mM]
3	Localization
2	Metals/Ions
2	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
11	Organism
3	Pathway
8	PDB ID
3	pH Optimum
5	Protein Variants
5	Purification (Commentary)
1	Reaction
10	Reference
12	Source Tissue
23	Substrates and Products (Substrate)
3	Subunits
23	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
7	Turnover Number [1/s]

Engineering

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Engineering on EC 2.5.1.92 - (2Z,6Z)-farnesyl diphosphate synthase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

D98E/S100Y/F107I

Solanum habrochaites

B8XA40

site-directed mutagenesis, mutant M3V1

737748

D98E/S100Y/L106I/F107I

Solanum habrochaites

B8XA40

site-directed mutagenesis, mutant M4

737748

S100Y/F107I

Solanum habrochaites

B8XA40

site-directed mutagenesis, mutant M2

737748

S100Y/L106I/F107I

Solanum habrochaites

B8XA40

site-directed mutagenesis, mutant M3V2

737748

additional information

Solanum habrochaites

B8XA40

change of 10 residues that correlate with changes in substrate in neryl diphosphate synthase, NDPS1, EC 2.5.1.28, from accession LA2409 to those found in zFPS, from accession LA1393 (Pro/Ser-45, which corresponds to the second residue in the predicted mature protein, is excluded), and reciprocal changes in zFPS (LA1393). The two resulting recombinant proteins are named NDPS1-M10 and zFPS-M10. The zFPS-M10 recombinant protein loses the ability to synthesize (2Z,6Z)-farnesyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate but gains NDPS1 activity and synthesizes neryl diphosphate at levels similar to enzyme NDPS1 from accession LA2409

737748