2.5.1.92: (2Z,6Z)-farnesyl diphosphate synthase

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For detailed information about (2Z,6Z)-farnesyl diphosphate synthase, go to the full flat file.

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Synonyms

cis,cis-farnesyl diphosphate synthase, cis-prenyltransferase, CPT1, FPPase, IDS3, More, short-chain cis-prenyldiphosphate synthase, short-chain SlCPT, SlCPT6, trans-isoprenyl diphosphate synthase, Z,Z-farnesyl diphosphate synthase, Z,Z-farnesyl pyrophosphate synthase, Z,Z-FPP synthase, zFPS

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.92 (2Z,6Z)-farnesyl diphosphate synthase

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Results	in table
3	AA Sequence
2	Application
5	Cloned(Commentary)
2	Crystallization (Commentary)
7	General Information
2	Inhibitors
7	kcat/KM [mM/s]
1	Ki Value [mM]
13	KM Value [mM]
3	Localization
2	Metals/Ions
2	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
11	Organism
3	Pathway
8	PDB ID
3	pH Optimum
5	Protein Variants
5	Purification (Commentary)
1	Reaction
10	Reference
12	Source Tissue
23	Substrates and Products (Substrate)
3	Subunits
23	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
7	Turnover Number [1/s]

General Information

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General Information on EC 2.5.1.92 - (2Z,6Z)-farnesyl diphosphate synthase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

evolution

3 entries

metabolism

Solanum habrochaites

B8XA40

in Solanum habrochaites accession LA1393, enzyme zFPS catalyzes the formation of (2Z,6Z)-farnesyl diphosphate,Z,Z-FPP, which is subsequently cyclized by santalene/bergamotene synthase (SBS) to form several sesquiterpenes

737748

physiological function

2 entries

additional information

Solanum habrochaites

B8XA40

homology modeling and three-dimensional structure

737748

evolution

Solanum lycopersicum

K7W9N9

all the short-chain CPT genes from tomato (SlCPT1, SlCPT2 and SlCPT6) are closely linked to terpene synthase gene clusters. Six of the seven tomato CPT genes, SlCPT1, SlCPT2, SlCPT4, SlCPT5, SlCPT6 and SlCPT7, are in phylogenetic group 1 of the CPT superfamily

723434

evolution

Solanum habrochaites

B8XA40

biochemical evolution of terpene biosynthesis in the glandular trichomes of Solanum species, comparative sequence analysis and evolutionary relationship of neryl diphosphate synthase 1 (EC 2.5.1.28, NDPS1) and (2Z,6Z)-farnesyl diphosphate synthase, cDNAs from the CPT1 locus, phylogenetic analysis, overview

737748

evolution

Solanum lycopersicum MP-1

-

all the short-chain CPT genes from tomato (SlCPT1, SlCPT2 and SlCPT6) are closely linked to terpene synthase gene clusters. Six of the seven tomato CPT genes, SlCPT1, SlCPT2, SlCPT4, SlCPT5, SlCPT6 and SlCPT7, are in phylogenetic group 1 of the CPT superfamily

-

physiological function

Plasmodium falciparum

-

the enzyme is a key enzyme in the metabolism of virtually all isoprenoids and it interconnects the 5-carbon moiety isoprenoid synthesis with the mid- or long-chained compound synthesis. The synthesis of farnesyl diphosphate and geranylgeranyl diphosphate is required for biosynthesis of ubiquinone, dolichol, carotenoids, menaquinone, tocopherol, and protein prenylation

738958

physiological function

Plasmodium falciparum clone 3D7

-

the enzyme is a key enzyme in the metabolism of virtually all isoprenoids and it interconnects the 5-carbon moiety isoprenoid synthesis with the mid- or long-chained compound synthesis. The synthesis of farnesyl diphosphate and geranylgeranyl diphosphate is required for biosynthesis of ubiquinone, dolichol, carotenoids, menaquinone, tocopherol, and protein prenylation

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