2.5.1.92: (2Z,6Z)-farnesyl diphosphate synthase
This is an abbreviated version!
For detailed information about (2Z,6Z)-farnesyl diphosphate synthase, go to the full flat file.
Word Map on EC 2.5.1.92
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2.5.1.92
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neryl
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terpene
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tomato
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trichomes
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longer-chain
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rnai-mediated
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thermococcus
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kodakaraensis
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cis-prenyltransferases
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lycopersicum
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solanum
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sesquiterpenes
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drug development
- 2.5.1.92
-
neryl
-
terpene
- tomato
-
trichomes
-
longer-chain
-
rnai-mediated
-
thermococcus
- kodakaraensis
- cis-prenyltransferases
- lycopersicum
- solanum
-
sesquiterpenes
- drug development
Reaction
+ 2 isopentenyl diphosphate = 2 diphosphate +
Synonyms
cis,cis-farnesyl diphosphate synthase, cis-prenyltransferase, CPT1, FPPase, IDS3, More, short-chain cis-prenyldiphosphate synthase, short-chain SlCPT, SlCPT6, trans-isoprenyl diphosphate synthase, Z,Z-farnesyl diphosphate synthase, Z,Z-farnesyl pyrophosphate synthase, Z,Z-FPP synthase, zFPS
ECTree
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General Information
General Information on EC 2.5.1.92 - (2Z,6Z)-farnesyl diphosphate synthase
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evolution
metabolism
in Solanum habrochaites accession LA1393, enzyme zFPS catalyzes the formation of (2Z,6Z)-farnesyl diphosphate,Z,Z-FPP, which is subsequently cyclized by santalene/bergamotene synthase (SBS) to form several sesquiterpenes
physiological function
additional information
homology modeling and three-dimensional structure
all the short-chain CPT genes from tomato (SlCPT1, SlCPT2 and SlCPT6) are closely linked to terpene synthase gene clusters. Six of the seven tomato CPT genes, SlCPT1, SlCPT2, SlCPT4, SlCPT5, SlCPT6 and SlCPT7, are in phylogenetic group 1 of the CPT superfamily
evolution
biochemical evolution of terpene biosynthesis in the glandular trichomes of Solanum species, comparative sequence analysis and evolutionary relationship of neryl diphosphate synthase 1 (EC 2.5.1.28, NDPS1) and (2Z,6Z)-farnesyl diphosphate synthase, cDNAs from the CPT1 locus, phylogenetic analysis, overview
evolution
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all the short-chain CPT genes from tomato (SlCPT1, SlCPT2 and SlCPT6) are closely linked to terpene synthase gene clusters. Six of the seven tomato CPT genes, SlCPT1, SlCPT2, SlCPT4, SlCPT5, SlCPT6 and SlCPT7, are in phylogenetic group 1 of the CPT superfamily
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the enzyme is a key enzyme in the metabolism of virtually all isoprenoids and it interconnects the 5-carbon moiety isoprenoid synthesis with the mid- or long-chained compound synthesis. The synthesis of farnesyl diphosphate and geranylgeranyl diphosphate is required for biosynthesis of ubiquinone, dolichol, carotenoids, menaquinone, tocopherol, and protein prenylation
physiological function
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the enzyme is a key enzyme in the metabolism of virtually all isoprenoids and it interconnects the 5-carbon moiety isoprenoid synthesis with the mid- or long-chained compound synthesis. The synthesis of farnesyl diphosphate and geranylgeranyl diphosphate is required for biosynthesis of ubiquinone, dolichol, carotenoids, menaquinone, tocopherol, and protein prenylation
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