2.5.1.74: 1,4-dihydroxy-2-naphthoate polyprenyltransferase
This is an abbreviated version!
For detailed information about 1,4-dihydroxy-2-naphthoate polyprenyltransferase, go to the full flat file.
Reaction
Synonyms
1,4-dihydroxy-2-naphthoate octaprenyltransferase, MenA
ECTree
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General Information
General Information on EC 2.5.1.74 - 1,4-dihydroxy-2-naphthoate polyprenyltransferase
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physiological function
the enzyme catalyzes the conversion of 1,4-dihydroxy-2-naphthoate to demethylmenaquinone. This step, prior to the methylation of demethylmenaquinone to menaquinone (vitamin K2), is a key reaction in menaquinone biosynthesis. Menaquinone is an obligatory component of the electron transfer pathway. Enzyme McMenA plays a role in the biosynthesis of cantharidin and ATP in Mylabris cichorii
additional information
the aspartate rich motif N/DDxxD representesbinding sites for prenyl diphosphate via a Mg2+ ion
additional information
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the aspartate rich motif N/DDxxD representesbinding sites for prenyl diphosphate via a Mg2+ ion