2.5.1.74: 1,4-dihydroxy-2-naphthoate polyprenyltransferase

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For detailed information about 1,4-dihydroxy-2-naphthoate polyprenyltransferase, go to the full flat file.

Reaction

Synonyms

1,4-dihydroxy-2-naphthoate octaprenyltransferase, MenA

ECTree

2 Transferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

2.5.1.74 1,4-dihydroxy-2-naphthoate polyprenyltransferase

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Results	in table
1	Activating Compound
14318	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
2	General Information
5	IC50 Value
7	Inhibitors
3	Localization
4	Metals/Ions
1	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
5	Organism
14	Pathway
1	pH Optimum
1	pI Value
1	Protein Variants
1	Reaction
5	Reference
7	Source Tissue
10	Substrates and Products (Substrate)
1	Subunits
4	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 2.5.1.74 - 1,4-dihydroxy-2-naphthoate polyprenyltransferase

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all-trans-polyprenyl diphosphate:1,4-dihydroxy-2-naphthoate polyprenyltransferase

This enzyme catalyses a step in the synthesis of menaquinone, in which the prenyl chain synthesized by polyprenyl diphosphate synthase is transferred to 1,4-dihydroxy-2-naphthoate (DHNA). The bacterial enzyme is an inner membrane protein [1], with the C-terminus located in the periplasm [3]. It is highly specific for DHNA but not for a specific length of the prenyl chain [2].