2.5.1.44: homospermidine synthase

This is an abbreviated version!
For detailed information about homospermidine synthase, go to the full flat file.

Word Map on EC 2.5.1.44

2.5.1.44

knee

arthroplasty

postoperative

pain

tibial

osteoarthritis

acquity

preoperative

fracture

acetonitrile

radiograph

formic

medial

femoral

radiological

osteotomy

loosening

flexion

varus

ultra-performance

satisfaction

inter-day

humic

womac

cement

radiolucent

cruciate

patella

mcmaster

arthroscopic

unicompartmental

uhplc

prostheses

lysholm

hepatosplenic

leadership

tegner

heterostructures

cementless

deoxyhypusine

malalignment

kellgren-lawrence

resurface

condylar

nonunion

precisions

posterolateral

meniscal

curricula

patellofemoral

Reaction

2 putrescine =

Synonyms

Atu3768, BvHSS, homospermidine synthase orthologue, HSPD synthase, HSS, HSS orthologue, synthase, homospermidine

ECTree

2 Transferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

2.5.1.44 homospermidine synthase

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Results	in table
452	AA Sequence
1	CAS Registry Number
10	Cloned(Commentary)
18	Cofactor
1	Crystallization (Commentary)
20	General Information
11	Inhibitors
3	kcat/KM [mM/s]
15	KM Value [mM]
6	Metals/Ions
7	Molecular Weight [Da]
20	Natural Substrates/ Products (Substrates)
33	Organism
4	Pathway
37	PDB ID
9	pH Optimum
4	Protein Variants
6	Purification (Commentary)
4	Reaction
1	Reaction Type
25	Reference
7	Source Tissue
5	Specific Activity [micromol/min/mg]
2	Storage Stability
49	Substrates and Products (Substrate)
4	Subunits
29	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
4	Temperature Stability [°C]
3	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.5.1.44 - homospermidine synthase

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putrescine:putrescine 4-aminobutyltransferase (ammonia-forming)

The reaction of this bacterial enzyme occurs in three steps, with some of the intermediates presumably remaining enzyme-bound: (a) NAD+-dependent dehydrogenation of either putrescine or spermidine, forming 4-iminobutan-1-amine or (E)-(4-aminobutylidene)(3-aminopropyl)amine, respectively, (b) attack by water forming 4-aminobutanal (and releasing ammonia or propane-1,3-diamine, respectively), and (c) condensation of 4-aminobutanal with putrescine, which forms homospermidine and restores NAD+. Differs from the eukaryotic enzyme EC 2.5.1.45, homospermidine synthase (spermidine-specific), which cannot use putrescine as donor of the aminobutyl group.