2.5.1.44: homospermidine synthase
This is an abbreviated version!
For detailed information about homospermidine synthase, go to the full flat file.
Word Map on EC 2.5.1.44
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2.5.1.44
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knee
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arthroplasty
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postoperative
-
pain
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tibial
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osteoarthritis
-
acquity
-
preoperative
-
fracture
-
acetonitrile
-
radiograph
-
formic
-
medial
-
femoral
-
radiological
-
osteotomy
-
loosening
-
flexion
-
varus
-
ultra-performance
-
satisfaction
-
inter-day
-
humic
-
womac
-
cement
-
radiolucent
-
cruciate
-
patella
-
mcmaster
-
arthroscopic
-
unicompartmental
-
uhplc
-
prostheses
-
lysholm
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hepatosplenic
-
leadership
-
tegner
-
heterostructures
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cementless
-
deoxyhypusine
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malalignment
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kellgren-lawrence
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resurface
-
condylar
-
nonunion
-
precisions
-
posterolateral
-
meniscal
-
curricula
-
patellofemoral
- 2.5.1.44
- knee
-
arthroplasty
-
postoperative
- pain
- tibial
- osteoarthritis
-
acquity
-
preoperative
-
fracture
- acetonitrile
-
radiograph
-
formic
-
medial
-
femoral
-
radiological
-
osteotomy
-
loosening
-
flexion
- varus
-
ultra-performance
-
satisfaction
-
inter-day
-
humic
-
womac
-
cement
-
radiolucent
-
cruciate
-
patella
-
mcmaster
-
arthroscopic
-
unicompartmental
-
uhplc
-
prostheses
-
lysholm
-
hepatosplenic
-
leadership
-
tegner
-
heterostructures
-
cementless
- deoxyhypusine
-
malalignment
-
kellgren-lawrence
-
resurface
-
condylar
-
nonunion
-
precisions
-
posterolateral
-
meniscal
-
curricula
-
patellofemoral
Reaction
Synonyms
Atu3768, BvHSS, homospermidine synthase orthologue, HSPD synthase, HSS, HSS orthologue, synthase, homospermidine
ECTree
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Reaction
Reaction on EC 2.5.1.44 - homospermidine synthase
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the reaction of this enzyme occurs in three steps: i. NAD-dependent dehydrogenation of putrescine, ii. transfer of the 4-aminobutylidene group from dehydroputrescine to a second molecule of putrescine, iii. reduction of the imine intermediate to form homospermidine. Hence the overall reaction is transfer of a 4-aminobutyl group. In the presence of putrescine, spermidine can function as a donor of the aminobutyl group, in which case, propane-1,3-diamine is released instead of ammonia. Differs from EC 2.5.1.45, homospermidine synthase, spermidine-specific, which cannot use putrescine as donor of the aminobutyl group
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2 putrescine = sym-homospermidine + NH3 + H+
the reaction mechanism emphasizes cation-Pi interaction through a conserved Trp residue as a key stabilizer of high energetic transition states. The enzyme has two distinct substrate binding sites, one of which is highly specific for putrescine. Enzyme HSS features a side pocket in the direct vicinity of the active site formed by conserved amino acids and a potential substrate discrimination, guiding, and sensing mechanism
putrescine + spermidine = sym-homospermidine + propane-1,3-diamine
the reaction mechanism emphasizes cation-Pi interaction through a conserved Trp residue as a key stabilizer of high energetic transition states. The enzyme has two distinct substrate binding sites, one of which is highly specific for putrescine. Enzyme HSS features a side pocket in the direct vicinity of the active site formed by conserved amino acids and a potential substrate discrimination, guiding, and sensing mechanism