2.5.1.116: homogentisate geranylgeranyltransferase
This is an abbreviated version!
For detailed information about homogentisate geranylgeranyltransferase, go to the full flat file.
Reaction
Synonyms
HGGT, homogentisic acid geranylgeranyl transferase, Hppt, slr1736
ECTree
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Substrates Products
Substrates Products on EC 2.5.1.116 - homogentisate geranylgeranyltransferase
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REACTION DIAGRAM
geranylgeranyl diphosphate + homogentisate
diphosphate + 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2
phytyl diphosphate + homogentisate
diphosphate + 2-methyl-6-phytylbenzene-1,4-diol + CO2
preferred substrate
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additional information
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no substrate: solanesyl diphosphate
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diphosphate + 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2
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the enzyme is involved in the biosynthesis of the vitamin E, tocotrienols. It uses primarily geranylgeranyl diphosphate as a substrate, but is capable of generating the 2-methyl-6-phytylbenzoquinol precursor of tocopherols, particularly in the presence of elevated ratios of phytyl diphosphate:geranylgeranyl diphosphate
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?
geranylgeranyl diphosphate + homogentisate
diphosphate + 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2
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the enzyme is six times more active (Vmax) with geranylgeranyl diphosphate than with phytyl diphosphate. Small difference in Km-value of geranylgeranyl diphosphate and phytyl diphosphate
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?
geranylgeranyl diphosphate + homogentisate
diphosphate + 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2
-
the enzyme is involved in the biosynthesis of the vitamin E, tocotrienols. It uses primarily geranylgeranyl diphosphate as a substrate, but is capable of generating the 2-methyl-6-phytylbenzoquinol precursor of tocopherols, particularly in the presence of elevated ratios of phytyl diphosphate:geranylgeranyl diphosphate
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-
?
geranylgeranyl diphosphate + homogentisate
diphosphate + 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2
-
the enzyme is six times more active (Vmax) with geranylgeranyl diphosphate than with phytyl diphosphate. Small difference in Km-value of geranylgeranyl diphosphate and phytyl diphosphate
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-
?
geranylgeranyl diphosphate + homogentisate
diphosphate + 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2
about 18% of the activity with phythyl diphosphate
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?