Information on EC 2.5.1.116 - homogentisate geranylgeranyltransferase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
2.5.1.116
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RECOMMENDED NAME
GeneOntology No.
homogentisate geranylgeranyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
geranylgeranyl diphosphate + homogentisate = diphosphate + 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of secondary metabolites
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Ubiquinone and other terpenoid-quinone biosynthesis
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vitamin E biosynthesis (tocotrienols)
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vitamin E metabolism
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SYSTEMATIC NAME
IUBMB Comments
geranylgeranyl diphosphate:homogentisate geranylgeranyltransferase
Requires Mg2+ for activity. Involved in the biosynthesis of the vitamin E, tocotrienols. While the enzyme from the bacterium Synechocystis PCC 6803 has higher activity with phytyl diphosphate (EC 2.5.1.115, homogentisate phytyltransferase), the enzymes from barley, rice and wheat have only a low activity with that substrate [2].
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
cv. Koshihikari, cv. Akitakomachi
UniProt
Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
geranylgeranyl diphosphate + homogentisate
diphosphate + 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2
show the reaction diagram
phytyl diphosphate + homogentisate
diphosphate + 2-methyl-6-phytylbenzene-1,4-diol + CO2
show the reaction diagram
preferred substrate
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?
additional information
?
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no substrate: solanesyl diphosphate
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
geranylgeranyl diphosphate + homogentisate
diphosphate + 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2
show the reaction diagram
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
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required
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00014
geranylgeranyl diphosphate
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pH and temperature not specified in the publication
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed under the control of the polyhedron promoter in Sf-9 cells using baculovirus-mediated transfection
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
expression analysis of HGGT in a set of contrasting red pericarp and light brown rice genotypes of advanced breeding lines together with their parents. Genotype G37 (red pericarp) shows higher expression than G7 (light brown) and G33 (red pericarp) at milky and mature grain development stages but lower than both parents. The transcript levels are comparatively low in mature grain
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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
synthesis
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combined expression of hydroxyphenylpyruvate dioxygenase/bi-functional chorismate mutase/prephenate dehydrogenase and homogentisate geranylgeranyl transferase in Arabidopsis leaves and seeds results in large additive increases in vitamin E production, indicating that homogentisate concentrations limit homogentisate geranylgeranyl transferase-catalyzed tocotrienol synthesis
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nutrition
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tocochromanol analysis in a set of contrasting red pericarp and light brown rice genotypes of advanced breeding lines together with their parents. The content of tocochromaols decreases in the order gamma-tocotrienol, alpha-tocopherol, alpha-tocotrienol, gamma-tocopherol, delta-tocotrienol, and total E vitamin content ranges from 10.30 to 31.65 microg/g