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2.5.1.114: tRNAPhe (4-demethylwyosine37-C7) aminocarboxypropyltransferase

This is an abbreviated version!
For detailed information about tRNAPhe (4-demethylwyosine37-C7) aminocarboxypropyltransferase, go to the full flat file.

Reaction

S-adenosyl-L-methionine
+
4-demethylwyosine37 in tRNAPhe
=
S-methyl-5'-thioadenosine
+
7-[(3S)-3-amino-3-carboxypropyl]-4-demethylwyosine37 in tRNAPhe

Synonyms

MJ1557, PH0793, TRM12, TYW2, YML005w

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.114 tRNAPhe (4-demethylwyosine37-C7) aminocarboxypropyltransferase

Engineering

Engineering on EC 2.5.1.114 - tRNAPhe (4-demethylwyosine37-C7) aminocarboxypropyltransferase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D293A
mutant enzyme retains activity
E265A
mutation eliminates activity
K225A
mutation eliminates activity
T248A
mutant enzyme retains activity
Y242A
mutant enzyme retains activity