2.5.1.1: dimethylallyltranstransferase

This is an abbreviated version!
For detailed information about dimethylallyltranstransferase, go to the full flat file.

Word Map on EC 2.5.1.1

2.5.1.1

farnesyl

monoterpene

prenyltransferases

terpenoids

ggpps

prenylation

geraniol

aspartate-rich

dmapp

tryptophan-containing

myrcene

carotenogenic

1-deoxy-d-xylulose-5-phosphate

uredovora

neosartorya

spearmint

oleoresin

Reaction

dimethylallyl diphosphate

+

isopentenyl diphosphate

=

diphosphate

+

geranyl diphosphate

Synonyms

(E)-geranyl diphosphate synthase, AnaPT, At4g36810, dimethylallyl transferase, ERG20, farnesyl diphosphate synthase, FgaPT2, FPPase, FPPS, FPPS2, geranyl diphosphate synthase, geranyl pyrophosphate synthase, geranylgeranyl pyrophosphate synthase, GGPPS11, GPP (C5) synthase, GPP synthase, GPP/FPP synthase, GPPS, HpGGPPS, IDS, IDS1, IDS2, IdsA, isoprenyl diphosphate synthase, PcIDS1, Rv0989c

ECTree

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

2.5.1.1 dimethylallyltranstransferase

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Results	in table
2661	AA Sequence
9	Cloned(Commentary)
4	Crystallization (Commentary)
24	Disease/ Diagnostics
2	Expression
10	General Information
46	IC50 Value
48	Inhibitors
4	kcat/KM [mM/s]
1	Ki Value [mM]
15	KM Value [mM]
6	Localization
7	Metals/Ions
8	Molecular Weight [Da]
32	Natural Substrates/ Products (Substrates)
66	Organism
16	Pathway
201	PDB ID
1	pH Optimum
2	pI Value
32	Protein Variants
6	Purification (Commentary)
1	Reaction
35	Reference
10	Source Tissue
1	Specific Activity [micromol/min/mg]
74	Substrates and Products (Substrate)
12	Subunits
50	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Stability [°C]
7	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 2.5.1.1 - dimethylallyltranstransferase

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0.000289

(4bR,8aS)-4b-(5-acetyl-1,3,4-oxadiazol-2-yl)-8,8-dimethyl-2-(propan-2-yl)-5,6,7,8,8a,9-hexahydrophenanthrene-3,4,10(4bH)-trione

Homo sapiens

pH 7.5, 23°C

0.000859

(4bR,8aS)-4b-(5-amino-1,3,4-oxadiazol-2-yl)-8,8-dimethyl-2-(propan-2-yl)-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-3,4-diol

Homo sapiens

pH 7.5, 23°C

0.0022

(4bR,8aS)-4b-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-8,8-dimethyl-2-(propan-2-yl)-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-3,4-diol

Homo sapiens

pH 7.5, 23°C

0.000335

(4bR,8aS)-4b-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-8,8-dimethyl-2-(propan-2-yl)-5,6,7,8,8a,9-hexahydrophenanthrene-3,4,10(4bH)-trione

Homo sapiens

pH 7.5, 23°C

0.000194

(4bR,8aS)-4b-(5-[(1S)-1-[(hydroxymethyl)amino]ethyl]-1,3,4-oxadiazol-2-yl)-8,8-dimethyl-2-(propan-2-yl)-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-3,4-diol

Homo sapiens

pH 7.5, 23°C

0.0251

(4bR,8aS)-4b-[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]-8,8-dimethyl-2-(propan-2-yl)-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-3,4-diol

Homo sapiens

pH 7.5, 23°C

0.0137

(4bR,8aS)-4b-[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]-8,8-dimethyl-2-(propan-2-yl)-5,6,7,8,8a,9-hexahydrophenanthrene-3,4,10(4bH)-trione

Homo sapiens

pH 7.5, 23°C

0.0011

(4bR,8aS)-4b-[5-[(dimethylamino)methyl]-1,3,4-oxadiazol-2-yl]-8,8-dimethyl-2-(propan-2-yl)-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-3,4-diol

Homo sapiens

pH 7.5, 23°C

0.0133

11,12-dihydroxy-7,20-epoxyabieta-8,11,13-trien-20-one

Homo sapiens

pH 7.5, 23°C

0.000914

11,12-dihydroxy-N-(2-hydroxyethyl)abieta-8(14),9(11),12-trien-20-amide

Homo sapiens

pH 7.5, 23°C

0.0027

11,12-dihydroxy-N-methylabieta-8(14),9(11),12-trien-20-amide

Homo sapiens

pH 7.5, 23°C

0.0027

11,12-dihydroxy-N-[(pyridin-3-yl)methyl]abieta-8(14),9(11),12-trien-20-amide

Homo sapiens

pH 7.5, 23°C

0.008

11,12-dihydroxy-N-[3-(1H-imidazol-1-yl)propyl]abieta-8(14),9(11),12-trien-20-amide

Homo sapiens

pH 7.5, 23°C

0.035

11,12-dihydroxyabieta-8(14),9(11),12-triene-20-hydrazide

Homo sapiens

pH 7.5, 23°C

0.0106

12-hydroxy-11,20-epoxyabieta-8(14),9(11),12-trien-20-one

Homo sapiens

pH 7.5, 23°C

0.0031

2-[11,12-dihydroxy-20-oxoabieta-8(14),9(11),12-trien-20-yl]hydrazine-1-carboxamide

Homo sapiens

pH 7.5, 23°C

0.0074

4-[5-[(4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-(propan-2-yl)-1,3,4,9,10,10a-hexahydrophenanthren-4a(2H)-yl]-1,3,4-oxadiazol-2-yl]benzonitrile

Homo sapiens

pH 7.5, 23°C

0.000389

6,20-epoxyabieta-8,13-diene-7,11,12,20-tetrone

Homo sapiens

pH 7.5, 23°C

0.0187

7,20-epoxyabieta-8(14),9(11),12-triene-11,12-diol

Homo sapiens

pH 7.5, 23°C

0.000473

7,20-epoxyabieta-8,13-diene-11,12,20-trione

Homo sapiens

pH 7.5, 23°C

0.000596

7,20-epoxyabieta-8,13-diene-11,12-dione

Homo sapiens

pH 7.5, 23°C

0.0078

abieta-8(14),9(11),12-triene-11,12,20-triol

Homo sapiens

pH 7.5, 23°C

0.028

methyl 11,12-dihydroxy-7-(phenylsulfanyl)abieta-8(14),9(11),12-trien-20-oate

Homo sapiens

pH 7.5, 23°C

0.0011

methyl 11,12-dihydroxy-7-methoxyabieta-8(14),9(11),12-trien-20-oate

Homo sapiens

pH 7.5, 23°C

0.0412

methyl 11,12-dihydroxy-7-oxoabieta-8(14),9(11),12-trien-20-oate

Homo sapiens

pH 7.5, 23°C

0.0013

methyl 11,12-dihydroxy-7-[(2-hydroxyethyl)sulfanyl]abieta-8(14),9(11),12-trien-20-oate

Homo sapiens

pH 7.5, 23°C

0.000833

methyl 11,12-dihydroxyabieta-7,9(11),13-trien-20-oate

Homo sapiens

pH 7.5, 23°C

0.000865

methyl 11,12-dihydroxyabieta-8(14),9(11),12-trien-20-oate

Homo sapiens

pH 7.5, 23°C

0.0563

methyl 11-[[tert-butyl(dimethyl)silyl]oxy]-12-hydroxyabieta-8(14),9(11),12-trien-20-oate

Homo sapiens

pH 7.5, 23°C

0.000523

methyl 7,11,12-trioxoabieta-8,13-dien-20-oate

Homo sapiens

pH 7.5, 23°C

0.0125

methyl 7-(butylsulfanyl)-11,12-dihydroxyabieta-8(14),9(11),12-trien-20-oate

Homo sapiens

pH 7.5, 23°C

0.0133

methyl 7-ethoxy-11,12-dihydroxyabieta-8(14),9(11),12-trien-20-oate

Homo sapiens

pH 7.5, 23°C

0.0086

methyl 7-ethoxy-11,12-dioxoabieta-8,13-dien-20-oate

Homo sapiens

pH 7.5, 23°C

0.000234

methyl 7-tert-butoxy-11,12-dioxoabieta-8,13-dien-20-oate

Homo sapiens

pH 7.5, 23°C

0.0227

methyl 7-[(2-hydroxyethyl)sulfanyl]-11,12-dioxoabieta-8,13-dien-20-oate

Homo sapiens

pH 7.5, 23°C

0.0008

N'-(4-bromobenzoyl)-11,12-dihydroxyabieta-8(14),9(11),12-triene-20-hydrazide

Homo sapiens

pH 7.5, 23°C

0.0015

N'-acetyl-11,12-dihydroxyabieta-8(14),9(11),12-triene-20-hydrazide

Homo sapiens

pH 7.5, 23°C

0.02564

N-acetyl-S-((4aR,10aS)-5,6-dihydroxy-7-isopropyl-4a-(methoxycarbonyl)-1,1-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-9-yl)-L-cysteine

Homo sapiens

pH 7.5, 23°C

0.00603

N-benzyl-11,12-dihydroxyabieta-8(14),9(11),12-trien-20-amide

Homo sapiens

pH 7.5, 23°C

0.008

N-[2-(dimethylamino)ethyl]-11,12-dihydroxy-7-oxoabieta-8(14),9(11),12-trien-20-amide

Homo sapiens

pH 7.5, 23°C

0.0012

N-[2-(dimethylamino)ethyl]-11,12-dihydroxyabieta-8(14),9(11),12-trien-20-amide

Homo sapiens

pH 7.5, 23°C

0.00052

tert-butyl [(1R)-1-amino-2-[2-[11,12-dihydroxy-20-oxoabieta-8(14),9(11),12-trien-20-yl]hydrazinyl]-2-oxoethyl]carbamate

Homo sapiens

pH 7.5, 23°C

0.0125

tert-butyl [(1R)-1-[5-[(4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-9-oxo-7-(propan-2-yl)-1,3,4,9,10,10a-hexahydrophenanthren-4a(2H)-yl]-1,3,4-oxadiazol-2-yl]ethyl]carbamate

Homo sapiens

pH 7.5, 23°C

0.000252

tert-butyl [(1S)-1-[5-[(4aR,10aS)-1,1-dimethyl-5,6,9-trioxo-7-(propan-2-yl)-1,3,4,5,6,9,10,10a-octahydrophenanthren-4a(2H)-yl]-1,3,4-oxadiazol-2-yl]ethyl]carbamate

Homo sapiens

pH 7.5, 23°C

0.000644

tert-butyl [(1S)-1-[5-[(4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-(propan-2-yl)-1,3,4,9,10,10a-hexahydrophenanthren-4a(2H)-yl]-1,3,4-oxadiazol-2-yl]ethyl]carbamate

Homo sapiens

pH 7.5, 23°C

0.0001

zoledronate

Homo sapiens

pH 7.5, 23°C

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Release 2023.1 (January 2023)