2.5.1.1: dimethylallyltranstransferase

This is an abbreviated version!
For detailed information about dimethylallyltranstransferase, go to the full flat file.

Reaction

Synonyms

(E)-geranyl diphosphate synthase, AnaPT, At4g36810, dimethylallyl transferase, ERG20, farnesyl diphosphate synthase, FgaPT2, FPPase, FPPS, FPPS2, geranyl diphosphate synthase, geranyl pyrophosphate synthase, geranylgeranyl pyrophosphate synthase, GGPPS11, GPP (C5) synthase, GPP synthase, GPP/FPP synthase, GPPS, HpGGPPS, IDS, IDS1, IDS2, IdsA, isoprenyl diphosphate synthase, PcIDS1, Rv0989c

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.1 dimethylallyltranstransferase

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Results	in table
2661	AA Sequence
9	Cloned(Commentary)
4	Crystallization (Commentary)
24	Disease/ Diagnostics
2	Expression
10	General Information
46	IC50 Value
48	Inhibitors
4	kcat/KM [mM/s]
1	Ki Value [mM]
15	KM Value [mM]
6	Localization
7	Metals/Ions
8	Molecular Weight [Da]
32	Natural Substrates/ Products (Substrates)
66	Organism
16	Pathway
201	PDB ID
1	pH Optimum
2	pI Value
32	Protein Variants
6	Purification (Commentary)
1	Reaction
35	Reference
10	Source Tissue
1	Specific Activity [micromol/min/mg]
74	Substrates and Products (Substrate)
12	Subunits
50	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Stability [°C]
7	Turnover Number [1/s]

Disease

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Disease on EC 2.5.1.1 - dimethylallyltranstransferase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Bone Diseases, Metabolic

Association Between Geranylgeranyl Pyrophosphate Synthase Gene Polymorphisms and Bone Phenotypes and Response to Alendronate Treatment in Chinese Osteoporotic Women.

28031082

Lymphoma, T-Cell

Roles of GTP and Rho GTPases in pancreatic islet beta cell function and dysfunction.

32867592

Multiple Myeloma

Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors.

30016091

Osteoporosis

Association Between Geranylgeranyl Pyrophosphate Synthase Gene Polymorphisms and Bone Phenotypes and Response to Alendronate Treatment in Chinese Osteoporotic Women.

28031082

Parasitic Diseases

Investigation of the catalytic mechanism of farnesyl pyrophosphate synthase by computer simulation.

16956297

Pneumonia

Inhibition of GGPPS1 attenuated LPS-induced acute lung injury and was associated with NLRP3 inflammasome suppression.

30652497

Tuberculosis

Arginine in the FARM and SARM: A Role in Chain-Length Determination for Arginine in the Aspartate-Rich Motifs of Isoprenyl Diphosphate Synthases from Mycobacterium tuberculosis.

30301210

Tuberculosis

Identification of a short (C15) chain Z-isoprenyl diphosphate synthase and a homologous long (C50) chain isoprenyl diphosphate synthase in Mycobacterium tuberculosis.

10816587

Tuberculosis

Mycobacterium tuberculosis Invasion and Traversal across an In Vitro Human Blood-Brain Barrier as a Pathogenic Mechanism for Central Nervous System Tuberculosis.

16586367

Tuberculosis

Purification, enzymatic characterization, and inhibition of the Z-farnesyl diphosphate synthase from Mycobacterium tuberculosis.

11152452

Tuberculosis

Rv0989c encodes a novel (E)-geranyl diphosphate synthase facilitating decaprenyl diphosphate biosynthesis in Mycobacterium tuberculosis.

21237161

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